BM6024P CD49c / CD49f (B Isoform specific) antibody

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0.1 mg / €320.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

Quick Overview

Mouse anti Human CD49c / CD49f PB36

Product Description for CD49c / CD49f

Mouse anti Human CD49c / CD49f PB36.
Properties: (B Isoform specific)
Presentation: Purified
Product is tested for Frozen Sections, Immunocytochemistry/Immunofluorescence, Western blot / Immunoblot.

Properties for CD49c / CD49f

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms Integrin alpha 3B / Integrin alpha 6B
Presentation Purified
Reactivity Hu
Applications C, ICC/IF, WB
Clonality Monoclonal
Clone PB36
Host Mouse
Isotype IgG1
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

PB36 is a mouse monoclonal IgG1, k antibody derived by fusion of SP2/0 mouse myeloma cells with spleen cells from a BALB/c mouse immunized with a synthetic peptide corresponding to a 32 amino acid stretch in the cytoplasmic domain of integrin α3B including an appending N-terminal cysteine coupled to keyhole limpet hemocyanin.
AA Sequence:
Property B Isoform specific
Application Suitable for Immunoblotting, Immunocytochemistry, Immunohistochemistry on frozen tissues.
Recommended Dilutions: 1/50-1/100 for Immunohistochemistry with avidin-biotinylated horseradish peroxidase complex (ABC) as detection reagent, and 1/100-1/500 for Immunoblotting applications.
Background Integrins are a family of heterodimeric membrane glycoproteins consisting of non-covalently associated a and b subunits. More than 18 a and 8 b subunits with numerous splice variant isoforms have been identified in mammals. In general, integrins function as receptors for extracellular matrix proteins. Certain integrins can also bind to soluble ligands or to counter-receptors on adjacent cells, such as the intracellular adhesion molecules (ICAMs), resulting in aggregation of cells. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis.
For integrin subunits a3 and a6, two cytoplasmic variants, A and B, have been identified.
Concentration 1.0 mg/ml
General Readings
  1. de Melker AA, Sterk LM, Delwel GO, Fles DL, Daams H, Weening JJ, et al. The A and B variants of the alpha 3 integrin subunit: tissue distribution and functional characterization. Lab Invest. 1997 Apr;76(4):547-63. PubMed PMID: 9111516.
Storage Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freeze-thaw cycles.
Shelf life: One year from despatch.
Buffer System:
PBS with 0.09% Sodium Azide as preservative.
Liquid purified IgG fraction.
Species Reactivity
Species reactivity (expected):
A broad species reactivity is expected because of the conserved nature of the epitope.
Species reactivity (tested):
This antibody recognizes the cytoplasmic domain of integrin subunits α3B and α6B.
PB36 reacts with the basement membrane zone and endothelial cells in skin, tubuli in kidney and all vascular and capillary endothelia in brain and heart.
A broad species reactivity is expected because of the conserved nature of the epitope.

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