NB100-65378 CD5 antibody

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0.125 mg / €360.00
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Quick Overview

Rat anti Canine CD5 YKIX322.3


Product Description for CD5

Rat anti Canine CD5 YKIX322.3.
Presentation: Aff - Purified
Product is tested for Frozen Sections, Immunoprecipitation, Flow Cytometry.

Properties for CD5

Product Category Primary Antibodies
Quantity 0.125 mg
Synonyms LEU-1, LEU1, Ly-1, Lymphocyte antigen T1/Leu-1, Lyt-1, T-cell surface glycoprotein CD5
Presentation Aff - Purified
Reactivity Can
Applications C, F, IP
Clonality Monoclonal
Clone YKIX322.3
Host Rat
Isotype IgG2a
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Concanavilin A activated canine peripheral blood cells.
Application flow cytometry / FACS analysis, Immunohistochemistry-Frozen, immunoprecipitation, Immunohistochemistry-Frozen, Immunoprecipitation, Flow cytometry / FACS analysis, flow cytometry / FACS analysis 1:50 - 1:100, immunoprecipitation , Immunohistochemistry-Frozen
Background In humans, CD5 is a 67kDa T lymphocyte single chain transmembrane glycoprotein. It is present on all mature T lymphocytes, on most thymocytes and on many T cell leukemias and lymphomas. It reacts with a subpopulation of activated B cells. CD5/Lyt1 antigen is a monomeric type I transmembrane glycoprotein expressed on thymocytes, T lymphocytes, and a subset of B lymphocytes, but not on natural killer (NK) cells. It has been identified as the major ligand of the B cell antigen CD72. The frequency of CD5+ B cells exhibits strain dependent variation, and the phenotypic, anatomical, functional, developmental, and pathological characteristics of the CD5+ B cells suggest that they may represent a distinct lineage, known as B1 cells. Binding of CD5 on the T cell surface can augment alloantigen or mitogen induced lymphocyte proliferation and induces increased cytosolic free calcium, IL2 secretion, and IL2R expression. It has been proposed that CD5 negatively regulates signal transduction mediated by the T cell and B cell receptors.
Concentration 1 mg/ml
Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
protein G purified
Buffer System:
0.09% Sodium Azide
protein G purified
Aff - Purified
Recognizes a 67kD cell surface glycoprotein expressed on the surface of T cells. Clustered as canine CD5 in the First Canine Leucocyte Antigen Workshop.

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