SM1584B CD5 antibody

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Mouse anti Feline CD5 FE1.1B11


Product Description for CD5

Mouse anti Feline CD5 FE1.1B11.
Presentation: Biotin
Product is tested for Flow Cytometry.

Properties for CD5

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms LEU-1, LEU1, Ly-1, Lymphocyte antigen T1/Leu-1, Lyt-1, T-cell surface glycoprotein CD5
Presentation Biotin
Reactivity Fe
Applications F
Clonality Monoclonal
Clone FE1.1B11
Host Mouse
Isotype IgG1
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Application Flow Cytometry: Neat - 1/10; Use 10 µl of the suggested working dilution to label 10e6 cells in 100µl.
Background CD5 is a 55kDa T lymphocyte single chain transmembrane glycoprotein. It is present on all mature T lymphocytes, on most thymocytes and on many T cell leukemias and lymphomas. It reacts with a subpopulation of activated B cells. CD5/Lyt1 antigen is a monomeric type I transmembrane glycoprotein expressed on thymocytes, T lymphocytes, and a subset of B lymphocytes, but not on natural killer (NK) cells. It has been identified as the major ligand of the B cell antigen CD72. The frequency of CD5+ B cells exhibits strain dependent variation, and the phenotypic, anatomical, functional, developmental, and pathological characteristics of the CD5+ B cells suggest that they may represent a distinct lineage, known as B1 cells. Binding of CD5 on the T cell surface can augment alloantigen or mitogen induced lymphocyte proliferation and induces increased cytosolic free calcium, IL2 secretion, and IL2R expression. It has been proposed that CD5 negatively regulates signal transduction mediated by the T cell and B cell receptors.
General Readings
  1. Power C, Buist R, Johnston JB, Del Bigio MR, Ni W, Dawood MR, et al. Neurovirulence in feline immunodeficiency virus-infected neonatal cats is viral strain specific and dependent on systemic immune suppression. J Virol. 1998 Nov;72(11):9109-15. PubMed PMID: 9765456. (Free PMC Article available, 6 images available)
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Affinity chromatography on Protein G
Buffer System:
PBS containing 0.09% Sodium Azide and 1% Bovine Serum Albumin
Liquid purified IgG
This antibody recognises CD5, a 67kD cell surface glycoprotein expressed by peripheral T lymphocytes and thymocytes.

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