discontinued

SM498 CD5 antibody

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2 ml / €450.00

Quick Overview

Mouse anti Equine CD5 CVS5

Product Description for CD5

Mouse anti Equine CD5 CVS5.
Presentation: Supernatant
Product is tested for Frozen Sections, Flow Cytometry.

Properties for CD5

Product Category Primary Antibodies
Quantity 2 ml
Synonyms LEU-1, LEU1, Ly-1, Lymphocyte antigen T1/Leu-1, Lyt-1, T-cell surface glycoprotein CD5
Presentation Supernatant
Reactivity Eq
Applications C, F
Clonality Monoclonal
Clone CVS5
Host Mouse
Isotype IgG1
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Immunogen
Immunogen:
Equine leucocytes. Spleen cells from immunised Balb/c mice were fused with cells of the mouse X63-Ag8.653 myeloma cell line.
Application Flow Cytometry.
Immunohistochemsistry on frozen sections.
Background CD5 is a 55kDa T lymphocyte single chain transmembrane glycoprotein. It is present on all mature T lymphocytes, on most thymocytes and on many T cell leukemias and lymphomas. It reacts with a subpopulation of activated B cells. CD5/Lyt1 antigen is a monomeric type I transmembrane glycoprotein expressed on thymocytes, T lymphocytes, and a subset of B lymphocytes, but not on natural killer (NK) cells. It has been identified as the major ligand of the B cell antigen CD72. The frequency of CD5+ B cells exhibits strain dependent variation, and the phenotypic, anatomical, functional, developmental, and pathological characteristics of the CD5+ B cells suggest that they may represent a distinct lineage, known as B1 cells. Binding of CD5 on the T cell surface can augment alloantigen or mitogen induced lymphocyte proliferation and induces increased cytosolic free calcium, IL2 secretion, and IL2R expression. It has been proposed that CD5 negatively regulates signal transduction mediated by the T cell and B cell receptors.
General Readings
  1. Lunn DP, Holmes MA, Duffus WP. Three monoclonal antibodies identifying antigens on all equine T lymphocytes, and two mutually exclusive T-lymphocyte subsets. Immunology. 1991 Oct;74(2):251-7. PubMed PMID: 1748472. (Free PMC Article available)
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
Buffer System:
Containing 0.09% Sodium Azide
State:
Liquid Tissue Culture Supernatant
Supernatant
Specificity
Specificity:
This antibody reacts with T lymphocytes but does not recognise B lymphocytes.
Species:
Horse.

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