AM32961FC-N CD59 antibody

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0.1 mg / €390.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

Quick Overview

Mouse anti Mouse CD59 7A6


Product Description for CD59

Mouse anti Mouse CD59 7A6.
Presentation: FITC
Product is tested for Enzyme Immunoassay, Immunocytochemistry/Immunofluorescence, Functional assay, Frozen Sections, Flow Cytometry, Western blot / Immunoblot.

Properties for CD59

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms 20 kDa homologous restriction factor, HRF-20, HRF20, MAC-IP, MAC-inhibitory protein, MACIF, MEM43 antigen, MIC11, MIN1, MIN2, MIN3, MIRL, MSK21, Membrane attack complex inhibition factor, Membrane inhibitor of reactive lysis, Protectin
Presentation FITC
Reactivity Ms
Applications C, E, F, FN, ICC/IF, WB
Clonality Monoclonal
Clone 7A6
Host Mouse
Isotype IgG1
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Swiss Prot Num:
Application Immuno Assays.
Western blot. 
Flow Cytometry.

Functional Studies. 
Immunohistochemistry on Frozen Sections. 
The typical starting working dilution is 1/50.
Background CD59 regulates the formation and function of the lytic C5b-9 complex by binding C8 and preventing the unfolding and membrane insertion of C9 and by binding C9 and restricting its polymerization.CD59 is a small (18 - 25 kDa) molecule, linked to the cell membrane through a glycosyl phosphatidylinositol (GPI) anchor and comprising 77 amino acids with a single N-linked carbohydrate group at Asn-18. Analogues of CD59 can be found in all species with similar structures and sizes. In contrast to all other species, mice have two genes encoding a CD59a and a CD59b protein. These two molecules are 63% identical at the amino acid level and share all major structural features. CD59a is broadly distributed on endothelia, erythrocytes, platelets and on numerous other cell types in organs, a distribution pattern resembling that of CD59 in other species. Expression of CD59b is restricted to germ cell elements in the testis and mature spermatozoa. Both CD59a and CD59b inhibit human and rodent complement with similar efficiency. CD59 may be involved in rheumatoid arthritis, motor nerve injury in the Guillain-Barré sydrome and in other diseases where defective inhibition of complement activation on self tissue is involved. Furthermore, CD59 may play an important part in abrogating the effects of complement attack in renal disease. Its presence and protective effect have already been demonstrated on human renal cells.
Concentration 0.1 mg/ml
General Readings
  1. Harris CL, Hanna SM, Mizuno M, Holt DS, Marchbank KJ, Morgan BP. Characterization of the mouse analogues of CD59 using novel monoclonal antibodies: tissue distribution and functional comparison. Immunology. 2003 May;109(1):117-26. PubMed PMID: 12709025. (Free PMC Article available, 7 images available)
  2. Williams AS, Mizuno M, Richards PJ, Holt DS, Morgan BP. Deletion of the gene encoding CD59a in mice increases disease severity in a murine model of rheumatoid arthritis. Arthritis Rheum. 2004 Sep;50(9):3035-44. PubMed PMID: 15457473.
  3. Willison, H et al; The role of complement and complement regulators in mediating motor nerve terminal injury in murine models of Guillain–Barré syndrome, J Neuroimmunol 2008, 201-202: 172
  4. Yang P, Tyrrell J, Han I, Jaffe GJ. Expression and modulation of RPE cell membrane complement regulatory proteins. Invest Ophthalmol Vis Sci. 2009 Jul;50(7):3473-81. doi: 10.1167/iovs.08-3202. Epub 2009 Jan 24. PubMed PMID: 19168900.
Storage Store undiluted at 2-8°C.
This product is photosensitive and should be protected from light.
Shelf life: one year from despatch.
Protein G Chromatography
Buffer System:
0.1% BSA
Liquid 0.2 µm filtered Ig fraction
Species Reactivity
Species reactivity (tested):
The monoclonal antibody 7A6 (previously known as mCD59.3) recognizes mouse CD59a, a potent inhibitor of the complement membrane attack complex (MAC) action.

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