SM1145R CD59 antibody

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100 Tests / €500.00
Please visit the country specific website of OriGene Technologies or contact your local Distributor to buy this product.

Quick Overview

Mouse anti Human CD59 MEM-43

Product Description for CD59

Mouse anti Human CD59 MEM-43.
Presentation: PE
Product is tested for Flow Cytometry.

Properties for CD59

Product Category Primary Antibodies
Target Category
Quantity 100 Tests
Synonyms 20 kDa homologous restriction factor, HRF-20, HRF20, MAC-IP, MAC-inhibitory protein, MACIF, MEM43 antigen, MIC11, MIN1, MIN2, MIN3, MIRL, MSK21, Membrane attack complex inhibition factor, Membrane inhibitor of reactive lysis, Protectin
Presentation PE
Reactivity Hu
Applications F
Clonality Monoclonal
Clone MEM-43
Host Mouse
Isotype IgG2a
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer OriGene Technologies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
P13987
GeneID:
966
Application Flow Cytometry.
Background CD59 is an LY6 like protein expressed in human lymphoid cells (haemapoietic and non- haemapoietic cells), regulates the action of the complement membrane attack complex on homologous cells. It is a potent inhibitor of the complement membrane attack complex action. It acts by binding to the C8 and/or C9 complements of the membrane attack complex, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. CD59 is also involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase
General Readings
  1. Stefanova, I. et al. (1989) in Leucocyte Typing IV: White cell differentiation antigens. Ed. Knapp, W. et al. Oxford University Press pp 678-697.
  2. Stefanova, I. et al. (1989) Characterisation of a broadly expressed human leucocyte antigen MEM-43 anchored in membrane through phosphotidylinositol. Mol. Immunol. 26: 153 - 161.
  3. Tandon N, Yan SL, Morgan BP, Weetman AP. Expression and function of multiple regulators of complement activation in autoimmune thyroid disease. Immunology. 1994 Apr;81(4):643-7. PubMed PMID: 7518800. (Free PMC Article available)
  4. Horejsí V, Angelisová P, Bazil V, Kristofová H, Stoyanov S, Stefanová I, et al. Monoclonal antibodies against human leucocyte antigens. II. Antibodies against CD45 (T200), CD3 (T3), CD43, CD10 (CALLA), transferrin receptor (T9), a novel broadly expressed 18-kDa antigen (MEM-43) and a novel antigen of restricted expression (MEM-74). Folia Biol (Praha). 1988;34(1):23-34. PubMed PMID: 2968928.
  5. Hadam, M. R. (1989) In Leucocyte Typing IV white cells differentiation antigens. Ed. Knapp, W. et al. Oxford University Press. pp 720 - 722.
  6. Stefanová I, Horejsí V. Association of the CD59 and CD55 cell surface glycoproteins with other membrane molecules. J Immunol. 1991 Sep 1;147(5):1587-92. PubMed PMID: 1715364.
Storage Prior to and following reconstitution store the antibody undiluted at 2-8°C.
DO NOT FREEZE!
This product is photosensitive and should be protected from light.
Shelf life: one year from despatch.
Format
Label:
R. Phycoerythrin (RPE)
PE
Purification:
Affinity chromatography on Protein A.
Buffer System:
BS, pH 7.4 containing 0.09% Sodium Azide as preservative and 1% BSA as stabilizer.
State:
Lyophilized purified IgG fraction.
Reconstitution:
Restore with distilled water.
Specificity
Specificity:
This antibody reacts with a PI-linked glycoprotein, Mw 18-20kD found on all types of leucocytes including platelets. MEM-43 has been shown to stimulate NK activity.
Species:
Human.
Gene ID 966
FocusOn and Reviews
FocusOns:

Accessory Products

Proteins and/or Positive Controls

Proteins for CD59 (5 products)

Catalog No. Species Pres. Purity   Source  

CD59 (transcript variant 2)

CD59 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €438.00
  OriGene Technologies, Inc.

CD59 (26-102, His-tag)

CD59 Human Purified > 85 % by SDS - PAGE E. coli
0.1 mg / €730.00
  OriGene Technologies GmbH

CD59 (26-102, His-tag)

CD59 Human Purified > 85 % by SDS - PAGE E. coli
20 µg / €300.00
  OriGene Technologies GmbH

CD59

CD59 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
  Abnova Taiwan Corp.

CD59

CD59 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
  Abnova Taiwan Corp.

Positive controls for CD59 (3 products)

Catalog No. Species Pres. Purity   Source  

CD59 293T Cell Transient Overexpression Lysate(Denatured)

CD59 293T Cell Transient Overexpression Lysate(Denatured)
  Abnova Taiwan Corp.

CD59 293T Cell Transient Overexpression Lysate(Denatured)

CD59 293T Cell Transient Overexpression Lysate(Denatured)
  Abnova Taiwan Corp.

CD59 Lysate

Western Blot: CD59 Lysate [NBL1-08958] - Western Blot experiments. 
Left-Control; Right -Over-expression Lysate for CD59
  Novus Biologicals Inc.
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