DM1205 CD66a/b/c/e antibody

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0.1 mg / €360.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

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Mouse anti Human CD66a/b/c/e TET2


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  • DM1205

Product Description for CD66a/b/c/e

Mouse anti Human CD66a/b/c/e TET2.
Presentation: Purified
Product is tested for Frozen Sections, Enzyme Immunoassay, Immunocytochemistry/Immunofluorescence, Western blot / Immunoblot, Flow Cytometry.

Properties for CD66a/b/c/e

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms BGP, CD66a, CD66b, CD66c, CD66d, CEACAM1, CEACAM5, CEACAM6, CEACAM8, Carcinoembryonic antigen-related cell adhesion molecule 1
Presentation Purified
Reactivity Hu
Applications C, E, F, ICC/IF, WB
Clonality Monoclonal
Clone TET2
Host Mouse
Isotype IgG2b
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

TET2 was generated by immunisation of BALB/c mice with CEA partially purified from a perchloric acid extract from liver metastases of colonic tumors (3).
Isotype control AM03110PU-N, SM12P
Add. information Selection: Based on recognition of the complete native protein expressed on transfected mammalian cells.
Application Flow Cytometry: 1.0 µg/106 cells.
ELISA: 1/200-1/400.
Cell based ELISA with intakt, transiently transfected cells: 1/200.
Western Blot: 4 µg/ml.
Immunohistology: 1-2 µg/106 cells (on Cryosections).
Background CEA-related cell adhesion molecules (CEACAM) belong to the carcinoembryonic antigen (CEA) family (1). The CEA family proteins belong to the immuno-globulin (Ig) superfamily and are composed of one Ig variable-like (IgV) and a varying number (0-6) of Ig constant-like (IgC) domains. CEACAM molecules are membrane-bound either via a transmembrane domain or a glycosyl phosphatidyl inositol (GPI) anchor. CEACAM molecules are differentially expressed in epithelial cells or in leucocytes. Over-expression of CEA/CEACAM5 in tumors of epithelial origin is the basis of its wide-spread use as a tumor marker (2). The function of CEACAM family members varies widely: they function as cell adhesion molecules, tumor suppressors, regulators of lymphocyte and dendritic cell activation, receptors of Neisseria species and other bacteria.
Concentration 1.0 mg/ml
Product Citations
Originator or purchased from resellers:
  1. Watt SM, Teixeira AM, Zhou GQ, Doyonnas R, Zhang Y, Grunert F, et al. Homophilic adhesion of human CEACAM1 involves N-terminal domain interactions: structural analysis of the binding site. Blood. 2001 Sep 1;98(5):1469-79. PubMed PMID: 11520797.
General Readings
  1. Zimmermann W (2002). Carcinoembryonic antigen. In Wiley Encyclopedia of Molecular Medicine (T. Creighton, ed.), John Wiley & Sons Inc., New York, USA, pp. 459-462.
  2. Hammarström S. The carcinoembryonic antigen (CEA) family: structures, suggested functions and expression in normal and malignant tissues. Semin Cancer Biol. 1999 Apr;9(2):67-81. PubMed PMID: 10202129.
  3. Grunert F, AbuHarfeil N, Schwarz K, von Kleist S. Two CEA and three NCA species, although distinguishable by monoclonal antibodies, have nearly identical peptide patterns. Int J Cancer. 1985 Sep 15;36(3):357-62. PubMed PMID: 3839768.
  4. Grunert F, Stocks SC, Nagel G, Zimmermann W, Thompson JA, Jantscheff P and Kromer B (1996). CD66 family Workshop: Binding of myeloid blind panel antibodies and CD66 Subsection antibodies to HeLa transfectants expressing individual CD66 molecules. In Leukocyte Typing VI: White cell Differentiation Antigens (T. Kishimoto et al., eds.), Garland Publishing Inc., New York and London, pp. 1012-1025.
Storage Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Affinity Chromatography on Protein G
Buffer System:
Phosphate buffered saline, pH 7.2
Liquid purified IgG fraction.
Species Reactivity
Species reactivity (tested):
This antibody recognizes CD66a/b/c/e.

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