DM1203 CD66c/e antibody

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0.1 mg / €330.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

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Mouse anti Human CD66c/e MUS


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  • DM1203
  • DM1203

Product Description for CD66c/e

Mouse anti Human CD66c/e MUS.
Presentation: Purified
Product is tested for Frozen Sections, Enzyme Immunoassay, Immunocytochemistry/Immunofluorescence, Western blot / Immunoblot, Flow Cytometry.

Properties for CD66c/e

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms CEA, CEACAM5, CEACAM6, Carcinoembryonic antigen, Carcinoembryonic antigen-related cell adhesion molecule 5, Meconium Antigen 100, NCA, Normal Cross-reacting Antigen
Presentation Purified
Reactivity Hu
Applications C, E, F, ICC/IF, WB
Clonality Monoclonal
Clone MUS
Host Mouse
Isotype IgG1
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

MUS was generated by immunisation of BALB/c mice with CEA partially purified from a perchloric acid extract from liver metastases of colonic tumors (3).
Application Flow Cytometry: 1.2 µg/106 cells.
ELISA: 1/200-1/400.
Cell based ELISA with intakt, transiently transfected cells: 1/200.
Western blot: 4 µg/ml.
Immunohistochemistry: 1-2 µg/106 cells (on Cryosections).
Background CEA-related cell adhesion molecules (CEACAM) belong to the carcinoembryonic antigen (CEA) family (1). The CEA family proteins belong to the immunoglobulin (Ig) superfamily and are composed of one Ig variable-like (IgV) and a varying number (0-6) of Ig constant-like (IgC) domains. CEACAM molecules are membrane-bound either via a transmembrane domain or a glycosyl phosphatidyl inositol (GPI) anchor. CEACAM molecules are differentially expressed in epithelial cells or in leucocytes. Over-expression of CEA/CEACAM5 in tumors of epithelial origin is the basis of its wide-spread use as a tumor marker (2). CEACAM6 expression is strongly upregulated already during early stages of adenocarcinoma formation (3). The function of CEA family members varies widely: they function as cell adhesion molecules, tumor suppressors, regulators of lymphocyte and dendritic cell activation, receptors of Neisseria species and other bacteria (1).
Concentration 1,0 mg/ml
Product Citations
Originator or purchased from resellers:
  1. Maraqa L. et al (2006): CEACAM: A potential novel predictor of breast cancer recurrence. AACR Meeting Abstracts 2006 : PR-8
  2. Tsutsumida H, Swanson BJ, Singh PK, Caffrey TC, Kitajima S, Goto M, et al. RNA interference suppression of MUC1 reduces the growth rate and metastatic phenotype of human pancreatic cancer cells. Clin Cancer Res. 2006 May 15;12(10):2976-87. PubMed PMID: 16707592.
General Readings
  1. Zimmermann W (2002). Carcinoembryonic antigen. In Wiley Encyclopedia of Molecular Medicine (T. Creighton, ed.), John Wiley & Sons Inc., New York, USA, pp. 459-462.
  2. Hammarström S. The carcinoembryonic antigen (CEA) family: structures, suggested functions and expression in normal and malignant tissues. Semin Cancer Biol. 1999 Apr;9(2):67-81. PubMed PMID: 10202129.
  3. Schölzel S, Zimmermann W, Schwarzkopf G, Grunert F, Rogaczewski B, Thompson J. Carcinoembryonic antigen family members CEACAM6 and CEACAM7 are differentially expressed in normal tissues and oppositely deregulated in hyperplastic colorectal polyps and early adenomas. Am J Pathol. 2000 Feb;156(2):595-605. PubMed PMID: 10666389. (Free PMC Article available, 3 images available)
  4. Grunert F, AbuHarfeil N, Schwarz K, von Kleist S. Two CEA and three NCA species, although distinguishable by monoclonal antibodies, have nearly identical peptide patterns. Int J Cancer. 1985 Sep 15;36(3):357-62. PubMed PMID: 3839768.
Storage Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Affinity Chromatography on Protein G
Buffer System:
Phosphate buffered saline, pH 7.2
Liquid purified IgG fraction
This antibody reacts to CD66c/e.

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