NB100-65005 CD66c/e antibody

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Mouse anti Human CD66c/e 198


Product Description for CD66c/e

Mouse anti Human CD66c/e 198.
Presentation: Aff - Purified
Product is tested for Frozen Sections, Flow Cytometry, Paraffin Sections.

Properties for CD66c/e

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms CD66c, CEACAM6, Carcinoembryonic antigen-related cell adhesion molecule 6, NCA, Non-specific crossreacting antigen, Normal cross-reacting antigen
Presentation Aff - Purified
Reactivity Hu
Applications C, F, P
Clonality Monoclonal
Clone 198
Host Mouse
Isotype IgG1
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Made to Human CD66ce
Application flow cytometry / FACS analysis, Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen and Paraffin, Flow cytometry / FACS analysis This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH6.0 is recommended for this purpose., flow cytometry / FACS analysis 1:50 - 1:100, Immunohistochemistry-Paraffin , Immunohistochemistry-Frozen
Background CEA-related cell adhesion molecules (CEACAM) belong to the carcinoembryonic antigen (CEA) family. It consists of seven CEACAM (CEACAM 1, CEACAM 3-CEACAM 8) and 11 pregnancy-specific glycoprotein (PSG1-PSG11) members. The CEA family proteins belong to the immunoglobulin (Ig) superfamily and are composed of one Ig variable like (IgV) and a varying number (0-6) of Ig constant-like (IgC) domains. CEACAM molecules are membrane-bound either via a transmembrane domain or a glycosyl phosphatidyl inositol (GPI) anchor. CEACAM molecules are differentially expressed in epithelial cells or in leucocytes. Over-expression of CEA/CEACAM 5 in tumors of epithelial origin is the basis of its wide-spread use as a tumor marker. CEACAM 6 expression is strongly up-regulated already during early stages of adenocarcinoma formation e.g. in colon. The function of CEA family members varies widely: they function as cell adhesion molecules, tumor suppressors, regulators of lymphocyte and dendritic cell activation, receptors of Neisseria species and other bacteria.
Concentration 1 mg/ml
Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
protein G purified
Buffer System:
0.09% Sodium Azide
protein G purified
Aff - Purified
NB100-65005 recognizes human CD66c and CD66e, members of the carcinoembryonic antigen family (NCA and CEA respectively). In flow cytometry this antibody stains peripheral blood granulocytes, but not monocytes or lymphocytes. In IHC the antibody stains a range of tumour cells and also neutrophils and some endothelial cells. Cross-reactivity with other members of the CEA family has not been reported, but has not been formally excluded.

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