SM024A CD8 antibody

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Rat anti Mouse CD8 YTS105.18

Product Description for CD8

Rat anti Mouse CD8 YTS105.18.
Presentation: Azide Free
Product is tested for Frozen Sections, Flow Cytometry.

Properties for CD8

Product Category Primary Antibodies
Quantity 1 mg
Synonyms CD8, MAL, T-cell surface glycoprotein CD8 alpha chain, T-cell surface glycoprotein CD8 beta chain, T-lymphocyte differentiation antigen T8/Leu-2
Presentation Azide Free
Reactivity Ms
Applications C, F
Clonality Monoclonal
Clone YTS105.18
Host Rat
Isotype IgG2a
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Mouse spleen cells. Spleen cells from an immunised DA rat were fused with cells of the rat Y3/Ag1.2.3. myeloma cell line.
Isotype control SM26A
Application Flow cytometry: 1/50 - 1/100; Use 10µl of the suggested working dilution to label 10e6 cells in 100µl.
Immunohistochemistry on frozen sections.
Concentration 1.0 mg/ml
General Readings
  1. Qin SX, Wise M, Cobbold SP, Leong L, Kong YC, Parnes JR, et al. Induction of tolerance in peripheral T cells with monoclonal antibodies. Eur J Immunol. 1990 Dec;20(12):2737-45. PubMed PMID: 1702726.
  2. Cobbold, S.P. et al. (1990) The Induction of skin graft tolerance in MHC-mis matched or primed recipients: primed T-cells can be tolerized in the periphery with CD4 and CD8 antibodies. Eur. J. Immunol. 20: 2747-2755.
  3. Wise MP, Bemelman F, Cobbold SP, Waldmann H. Linked suppression of skin graft rejection can operate through indirect recognition. J Immunol. 1998 Dec 1;161(11):5813-6. PubMed PMID: 9834057.
Storage Store the antibody at -20°C.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Affinity chromatography on Protein G
Buffer System:
PBS, pH7.4
Liquid purified IgG
Azide Free
This antibody recognises a non polymorphic epitope on the CD8 alpha chain. Blocks MHC I dependent T cell responses in vitro and in vivo, and induces transplantation tolerance in combination with CD4 antibodies.

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