NB120-482 Cdc34 antibody

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0.05 ml / €420.00

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Mouse anti Human Cdc34


Product Description for Cdc34

Mouse anti Human Cdc34.
Presentation: Serum
Product is tested for Immunoprecipitation, Western blot / Immunoblot.

Properties for Cdc34

Product Category Primary Antibodies
Quantity 0.05 ml
Presentation Serum
Reactivity Hu
Applications IP, WB
Clonality Polyclonal
Host Mouse
Isotype IgG
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

N-terminally 6x-His tagged fusion protein encoding full-length human Cdc34 expressed in E. coli.
Background Cdc34 is a ubiquitin conjugating enzyme (UBC) or E2 that has been shown to be essential for the G1 to S phase transition in yeast. Human Cdc34 fully complements the budding yeast Cdc34 temperature sensitive mutant phenotype. In egg extracts of the frog Xenopus laevis, Cdc34 has been shown to be required for the onset of DNA replication and appears to function in a multi-protein complex. Also, Cdc34 is highly conserved among vertebrates and is likely to function in a similar manner in all eukaryotes to regulate the start of DNA synthesis.
General Readings General / background references:Koepp DM et al. How the cyclin became a cyclin: regulated proteolysis in the cell cycle. Cell 97:431-4 (1999). PubMed PMID: 10338207
Tyers M & Willems AR One ring to rule a superfamily of E3 ubiquitin ligases. Science 284:601, 603-4 (1999). PubMed PMID: 10328744
Yew PR & Kirschner MW Proteolysis and DNA replication: the CDC34 requirement in the Xenopus egg cell cycle. Science 277:1672-6 (1997). PubMed PMID: 9287222
Goebl MG et al. The yeast cell cycle gene CDC34 encodes a ubiquitin-conjugating enzyme. Science 241:1331-5 (1988). PubMed PMID: 2842867
Whole antisera
Buffer System:
Whole antisera
Cross-reacts with Human.Not yet tested in other species.

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