Product Description for CDC42
Chicken anti Human, Mouse, Rat CDC42.
Presentation: Aff - Purified
Product is tested for Western blot / Immunoblot.
Presentation: Aff - Purified
Product is tested for Western blot / Immunoblot.
Properties for CDC42
| Product Category | Primary Antibodies |
|---|---|
| Quantity | 0.05 mg |
| Presentation | Aff - Purified |
| Reactivity | Hu, Ms, Rt |
| Applications | WB |
| Clonality | Polyclonal |
| Host | Chicken |
| Shipping to | Not USA/Canada |
| PDF datasheet | View Datasheet |
| Manufacturer | Novus Biologicals Inc. |
Datasheet Extract
| Immunogen |
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|---|---|
| Application | Western Blot |
| Background | This protein is a small GTPase of the Rho subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc42, and is able to complement the yeast cdc42 1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott Aldrich syndrome protein (NWASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in at least two transcript variants. |
| General Readings | 1. Hui,E.K., Barman,S., Tang,D.H., France,B. and Nayak,D.P., et al. YRKL sequence of influenza virus M1 functions as the L domain motif and interacts with VPS28 and Cdc42 2. Broman,M.T., Kouklis,P., Gao,X., Ramchandran,R., Neamu,R.F., Minshall,R.D. and Malik,A.B. Cdc42 regulates adherens junction stability and endothelial permeability by inducing alpha-catenin interaction with the vascular endothelial cadherin complex 3. Du,Y., Bock,B.C., Schachter,K.A., Chao,M. and Gallo,K.A., et al. Cdc42 induces activation loop phosphorylation and membrane targeting of mixed lineage kinase 3 4. Jung,J.H. and Traugh,J.A., et al. Regulation of the interaction of Pak2 with Cdc42 via autophosphorylation of serine 141 5. Chang,J.C., Chang,H.H., Lin,C.T. and Lo,S.J., et al. The integrin alpha6beta1 modulation of PI3K and Cdc42 activities induces dynamic filopodium formation in human platelets 6. , Moats-Staats B.M., Jarvis H.W., D'Ercole A.J., Stiles A.D. Cloning and characterization of a novel RNA involved in cellular growth regulation. |
| Storage | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
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Accessory Products
Recommended Secondary Antibodies for CDC42 (8 products)
| Catalog No. | Host | Clone/Iso. | Pres. | React. | Applications | ||
|---|---|---|---|---|---|---|---|
| R1300AP |
Chicken IgG / Chicken IgY (H+L chain) antibody |
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|
Rabbit | AP | |||||
| Acris Antibodies GmbH | |||||||
| R1300B |
Chicken IgG / Chicken IgY (H+L chain) antibody |
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|
|
Rabbit | Biotin | |||||
| Acris Antibodies GmbH | |||||||
| R1300F |
Chicken IgG / Chicken IgY (H+L chain) antibody |
||||||
|
|
Rabbit | FITC | F, ICC/IF | ||||
| Acris Antibodies GmbH | |||||||
| R1300HRP |
Chicken IgG / Chicken IgY (H+L chain) antibody |
||||||
|
|
Rabbit | HRP | |||||
| Acris Antibodies GmbH | |||||||
| R1300T |
Chicken IgG / Chicken IgY (H+L chain) antibody |
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|
|
Rabbit | TRITC | |||||
| Acris Antibodies GmbH | |||||||
| R1434C2 |
Chicken IgG / Chicken IgY (H+L chain), adsorbed antibody |
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|
|
Goat | Cy2 | |||||
| Acris Antibodies GmbH | |||||||
| R1434C3 |
Chicken IgG (H&L) multi-species ads. antibody |
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|
|
Goat | Cy3 | |||||
| Acris Antibodies GmbH | |||||||
| R1434C5 |
Chicken IgG / Chicken IgY (H+L chain, adsorbed) antibody |
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|
|
Goat | Cy5 | |||||
| Acris Antibodies GmbH | |||||||
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