NB100-75550 CDC42 antibody

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Chicken anti Human, Mouse, Rat CDC42


Product Description for CDC42

Chicken anti Human, Mouse, Rat CDC42.
Presentation: Aff - Purified
Product is tested for Western blot / Immunoblot.

Properties for CDC42

Product Category Primary Antibodies
Quantity 0.05 mg
Presentation Aff - Purified
Reactivity Hu, Ms, Rt
Applications WB
Clonality Polyclonal
Host Chicken
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

The immunogen for this antibody was a sequence from 1a.a. to 191a.a. from CDC42(a 191a.a. long protein)
Application Western Blot
Background This protein is a small GTPase of the Rho subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc42, and is able to complement the yeast cdc42 1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott Aldrich syndrome protein (NWASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in at least two transcript variants.
General Readings 1. Hui,E.K., Barman,S., Tang,D.H., France,B. and Nayak,D.P., et al.
YRKL sequence of influenza virus M1 functions as the L domain motif and interacts with VPS28 and Cdc42
2. Broman,M.T., Kouklis,P., Gao,X., Ramchandran,R., Neamu,R.F., Minshall,R.D. and Malik,A.B.
Cdc42 regulates adherens junction stability and endothelial permeability by inducing alpha-catenin interaction with the vascular endothelial cadherin complex
3. Du,Y., Bock,B.C., Schachter,K.A., Chao,M. and Gallo,K.A., et al.
Cdc42 induces activation loop phosphorylation and membrane targeting of mixed lineage kinase 3
4. Jung,J.H. and Traugh,J.A., et al.
Regulation of the interaction of Pak2 with Cdc42 via autophosphorylation of serine 141
5. Chang,J.C., Chang,H.H., Lin,C.T. and Lo,S.J., et al.
The integrin alpha6beta1 modulation of PI3K and Cdc42 activities induces dynamic filopodium formation in human platelets
6. , Moats-Staats B.M., Jarvis H.W., D'Ercole A.J., Stiles A.D.
Cloning and characterization of a novel RNA involved in cellular growth regulation.
Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Immunogen affinity purified
Buffer System:
Phosphate-Buffered Saline.
Immunogen affinity purified
Aff - Purified
This antibody is reactive against Human, mouse, rat.

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