NB100-75555 CDKN1B / KIP1 antibody

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50 µg / €520.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

Quick Overview

Chicken anti Chicken CDKN1B / KIP1

Product Description for CDKN1B / KIP1

Chicken anti Chicken CDKN1B / KIP1.
Presentation: Aff - Purified
Product is tested for Western blot / Immunoblot.

Properties for CDKN1B / KIP1

Product Category Primary Antibodies
Quantity 50 µg
Synonyms Cyclin-dependent kinase inhibitor 1B, Cyclin-dependent kinase inhibitor p27, p27Kip1
Presentation Aff - Purified
Reactivity Chk
Applications WB
Clonality Polyclonal
Host Chicken
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Swiss Prot Num:
The immunogen for this antibody was a sequence from 1a.a. to 198a.a. from p27 KIP1(a 198a.a. long protein)
Add. information Research Areas: Cancer
Application Western Blot, This antibody is useful for Western Blot., Western Blot
Background Cell cycle progression is regulated by cyclins and their cognate Cdks. p27 KIP 1 is a cell cycle regulatory mitotic inhibitor of cdk activity. p27 KIP 1 is a candidate tumor suppressor gene, and has been proposed to function as a possible mediator of TGF beta induced G1 arrest. p27 KIP 1 is up regulated in response to antimitogenic stimuli. The increased protein expression of p27 results in cellular arrest by binding to cyclin/Cdk complexes such as cyclin D1/Cdk4. p27 Kip1 is regulated by phosphorylation on serine 10 (S10) and threonine 187 (T187). Phosphorylation by CDK2 on T187 results in ubiquitylation and degradation of p27 Kip 1; while phosphorylation by hKIS on S10 signals the nuclear export to the cytoplasm.
General Readings 1. Caldwell,R.B., Kierzek,A.M., Arakawa,H., Bezzubov,Y., Zaim,J., Fiedler,P., Kutter,S., Blagodatski,A., Kostovska,D., Koter,M.,, et al.
Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis
2. , Chen D., Boulme F., Dolznig H., Mullner E.W.
Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
3. , Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P., Kutter S., Blagodatski A., Kostovska D., Koter M., et al.
Full-length cDNAs from chicken bursal lymphocytes to facilitate genefunction analysis.
Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Immunogen affinity purified
Buffer System:
No Preservative
Immunogen affinity purified
Aff - Purified
p27 KIP1
Gene ID 374106

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