SM1075PS CDw17 antibody

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Mouse anti Human CDw17 MEM-74


Product Description for CDw17

Mouse anti Human CDw17 MEM-74.
Presentation: Purified
Product is tested for Agglutination, Frozen Sections, Flow Cytometry, Paraffin Sections.

Properties for CDw17

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms Lactosylceramide
Presentation Purified
Reactivity Hu
Applications AGG, C, F, P
Clonality Monoclonal
Clone MEM-74
Host Mouse
Isotype IgM
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Pre-B cell line NALM-6
Isotype control SM13P
Application Flow Cytometry: 10 µg/ml.
Immunohistochemistry on Frozen and Paraffin Sections.
Agglutination: The antibody MEM-74 agglutinates neuraminidase-treated erythrocytes of blood group p.
Background CD17, lactosylceramide, is an ubiquitous glycosphingolipid with uncharged disaccharide headgroup, highly enriched in lipid raft-derived structures. Besides playing a pivotal role in the biosynthesis of complex glycosphingilipids, lactosylceramide is involved in cell-cell and cell-matrix interactions and in signaling events linked to cell differentiation, development, apoptosis and oncogenesis. Lactosylceramide regulates integrin functions and production of nitric oxide. Its expression defines successive stages in the maturation of myeloid cells.
Concentration 1.0 mg/ml
General Readings
  1. Bhunia AK, Arai T, Bulkley G, Chatterjee S. Lactosylceramide mediates tumor necrosis factor-alpha-induced intercellular adhesion molecule-1 (ICAM-1) expression and the adhesion of neutrophil in human umbilical vein endothelial cells. J Biol Chem. 1998 Dec 18;273(51):34349-57. PubMed PMID: 9852101.
  2. Spychalska J, Smoleńska-Sym G, Zdebska E, Woźniak J, Kościelak J. Quantitative analysis of LacCer/CDw17 in human myelogenous leukaemic cells. Cell Mol Biol Lett. 2003;8(4):911-7. PubMed PMID: 14668914.
  3. Pannu R, Singh AK, Singh I. A novel role of lactosylceramide in the regulation of tumor necrosis factor alpha-mediated proliferation of rat primary astrocytes. Implications for astrogliosis following neurotrauma. J Biol Chem. 2005 Apr 8;280(14):13742-51. Epub 2005 Jan 24. PubMed PMID: 15668227.
  4. Sharma DK, Brown JC, Cheng Z, Holicky EL, Marks DL, Pagano RE. The glycosphingolipid, lactosylceramide, regulates beta1-integrin clustering and endocytosis. Cancer Res. 2005 Sep 15;65(18):8233-41. PubMed PMID: 16166299.
  5. Zhai X, Li XM, Momsen MM, Brockman HL, Brown RE. Lactosylceramide: lateral interactions with cholesterol. Biophys J. 2006 Oct 1;91(7):2490-500. Epub 2006 Jul 7. PubMed PMID: 16829567. (Free PMC Article available, 8 images available)
  6. Horejsí V, Angelisová P, Bazil V, Kristofová H, Stoyanov S, Stefanová I, et al. Monoclonal antibodies against human leucocyte antigens. II. Antibodies against CD45 (T200), CD3 (T3), CD43, CD10 (CALLA), transferrin receptor (T9), a novel broadly expressed 18-kDa antigen (MEM-43) and a novel antigen of restricted expression (MEM-74). Folia Biol (Praha). 1988;34(1):23-34. PubMed PMID: 2968928.
  7. Leukocyte Typing IV., Knapp W. et al. (Eds.), Oxford University Press (1989).
Storage Store the anibody at 2-8°C.
Shelf life: one year from despatch.
Gel Filtration and Precipitation Methods
Buffer System:
Tris buffered saline, pH~8.0, with 15 mM Sodium Azide as preservative
Liquid purified Ig fraction (>95% pure by SDS-PAGE)
The antibody recognizes CD17, a membrane lipid moiety lactosylceramide expressed on granulocytes, monocytes and platelets.

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