AP05210PU-N Ceremide Kinase antibody

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0.1 mg / €480.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

Quick Overview

Rabbit anti Human Ceremide Kinase


Product Description for Ceremide Kinase

Rabbit anti Human Ceremide Kinase.
Presentation: Purified
Product is tested for Enzyme Immunoassay, Western blot / Immunoblot.

Properties for Ceremide Kinase

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms Acylsphingosine kinase, LK4, Lipid kinase 4, hCERK
Presentation Purified
Reactivity Hu
Applications E, WB
Clonality Polyclonal
Host Rabbit
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Recombinant full-length human ceramide kinase protein
Application ELISA.
Western Blot: 1 - 10 µg/ml.
Positive Control: High level expression in heart, brain, skeletal muscle, kidney and liver.
Background Sphingolipids and their metabolic products, including ceramide, sphingosine, and sphingosine-1-phosphate (S1P),1 are important signaling molecules in many biological processes. Ceramide has been is one of the key elements regulating apoptotic responses. Ceramide has been reported as a regulator of several protein kinases and phosphatases, including ceramide-activated protein kinase, protein phosphatase, and protein kinase C. Sphingosine, a metabolite of ceramide, might also play a role in mitochondriamediated apoptosis. Sphingosine inhibits several protein kinases, including protein kinase C and Ca2 -calmodulin-dependent kinase II. S1P regulates many biological processes, including mitogenesis, differentiation, migration, and suppression of apoptosis.
Concentration Lot specific
General Readings
  1. Lamour NF, Chalfant CE. Ceramide-1-phosphate: the "missing" link in eicosanoid biosynthesis and inflammation. Mol Interv. 2005 Dec;5(6):358-67. PubMed PMID: 16394251.
  2. Kim JW, Inagaki Y, Mitsutake S, Maezawa N, Katsumura S, Ryu YW, et al. Suppression of mast cell degranulation by a novel ceramide kinase inhibitor, the F-12509A olefin isomer K1. Biochim Biophys Acta. 2005 Dec 30;1738(1-3):82-90. Epub 2005 Nov 14. PubMed PMID: 16352467.
  3. Van Overloop H, Gijsbers S, Van Veldhoven PP. Further characterization of mammalian ceramide kinase: substrate delivery and (stereo)specificity, tissue distribution, and subcellular localization studies. J Lipid Res. 2006 Feb;47(2):268-83. Epub 2005 Nov 3. PubMed PMID: 16269826.
  4. Chalfant CE, Spiegel S. Sphingosine 1-phosphate and ceramide 1-phosphate: expanding roles in cell signaling. J Cell Sci. 2005 Oct 15;118(Pt 20):4605 - 12. Review.
  5. Mitsutake S, Igarashi Y. Calmodulin is involved in the Ca2+-dependent activation of ceramide kinase as a calcium sensor. J Biol Chem. 2005 Dec 9;280(49):40436-41. Epub 2005 Oct 3. PubMed PMID: 16203736.
  6. Wijesinghe DS, Massiello A, Subramanian P, Szulc Z, Bielawska A, Chalfant CE. Substrate specificity of human ceramide kinase. J Lipid Res. 2005 Dec;46(12):2706-16. Epub 2005 Sep 18. PubMed PMID: 16170208.
  7. Kim TJ, Mitsutake S, Kato M, Igarashi Y. The leucine 10 residue in the pleckstrin homology domain of ceramide kinase is crucial for its catalytic activity. FEBS Lett. 2005 Aug 15;579(20):4383-8. PubMed PMID: 16081073.
Storage The antibody can be shipped at ambient temperature. Store (in aliquots) at -20°C only.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Buffer System:
Phosphate buffered saline with 0.08% sodium azide
Liquid purified Ig
This antibody reacts to Ceremide Kinase.

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