SM2184P Chimaeric human IgA2 anti Nitrophenyl-hapten (NP) antibody

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Human anti Chimaeric human IgA2 anti Nitrophenyl-hapten (NP) JW393A


Product Description for Chimaeric human IgA2 anti Nitrophenyl-hapten (NP)

Human anti Chimaeric human IgA2 anti Nitrophenyl-hapten (NP) JW393A.
Presentation: Purified

Properties for Chimaeric human IgA2 anti Nitrophenyl-hapten (NP)

Product Category Primary Antibodies
Quantity 0.5 mg
Presentation Purified
Clonality Monoclonal
Clone JW393A
Host Human
Isotype IgA
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Application ELISA.
Concentration 1.0 mg/ml
General Readings
  1. Neuberger MS, Williams GT, Fox RO. Recombinant antibodies possessing novel effector functions. Nature. 1984 Dec 13-19;312(5995):604-8. PubMed PMID: 6095112.
  2. Neuberger, M.S. et al. (1985) Making Novel Antibodies by expressing transfected immunoglobulin genes. TIBS 347-349.
  3. Neuberger MS, Williams GT, Mitchell EB, Jouhal SS, Flanagan JG, Rabbitts TH. A hapten-specific chimaeric IgE antibody with human physiological effector function. Nature. 1985 Mar 21-27;314(6008):268-70. PubMed PMID: 2580239.
  4. Neuberger, M.S. et al. (1986) Construction of novel antibodies by use of DNA transfection: design of plasmid vectors. Phil. Trans. R. Soc. London. A317: 425-432.
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Affinity chromatography using NIP cap-sepharose
Buffer System:
PBS containing 0.09% Sodium Azide as preservative
Liquid purified IgA fraction
The immunoglobulin heavy chain has been produced by the linking of the IgA2 antigen-binding, variable region genes of a mouse hybridoma to human constant region genes by in vitro DNA recombination procedures. The resulting chimaeric antibody is subsequently expressed by the myeloma cell-line J558L after transfection. The J558L cell-line itself secretes a lambda light chain but no heavy chain. Thus a chimaeric human IgA2 antibody specific for NP has been produced. This antibody may be used for studying the effector functions of the different human immunoglobulin classes and subclasses and for diagnostic and therapeutic research. Provision of a source of highly pure human immunoglobulin class and subclass for quantitating human immunoglobulins in serum.

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