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TA500405 CHK2 antibody

CHEK2 (CHK2) mouse monoclonal antibody, clone OTI2F4 (formerly 2F4)

Search for all "CHK2"

0.1 ml / €350.00

Please visit the country specific website of OriGene Technologies or contact your local Distributor to buy this product.

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Highly validated antibody!

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Mouse anti Canine, Human, Monkey, Rat CHK2 OTI2F4

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Product Description for CHK2

Mouse anti Canine, Human, Monkey, Rat CHK2 OTI2F4.
Presentation: Purified
Product is tested for Flow Cytometry, Immunocytochemistry/Immunofluorescence, Western blot / Immunoblot.

Properties for CHK2

Product Category	Primary Antibodies
Target Category	CHK2 antibody
Quantity	0.1 ml
Synonyms	CHEK-2, CHEK2, CHK-2, CHK2 checkpoint homolog, Cds1, RAD53, Serine/threonine-protein kinase Chk2
Presentation	Purified
Reactivity	Can, Hu, Mky, Rt
Applications	F, ICC/IF, WB
Clonality	Monoclonal
Clone	OTI2F4
Host	Mouse
Isotype	IgG2b
Shipping to	Europe, USA/Canada
PDF datasheet	View Datasheet
Manufacturer	OriGene Technologies, Inc.

Datasheet Extract

Immunogen	Swiss Prot Num: O96017 Immunogen: Full length human recombinant protein of human CHEK2 (NP_009125) produced in HEK293T cell. GeneID: 11200
Isotype control	AM03110PU-N, SM12P
Application	WB 1:500~1000 IF 1:50~100 FLOW 1:100
Background	In response to D damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to D damage and is rapidly phosphorylated in response to replication blocks and D damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition,this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after D damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors.This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kises. Three transcript variants encoding different isoforms have been found for this gene.
Format	Purification: Purified from mouse ascites fluids by affinity chromatography Buffer System: PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide. State: Purified

Accessory Products

Proteins and/or Positive Controls

Proteins for CHK2 (6 products)

Catalog No.	Species	Purity	Source
TP301278	CHK2 (transcript variant 1)
	Human	> 80 % Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps. Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.	HEK293 cells	20 µg / €438.00
				OriGene Technologies, Inc.
H00011200-P01-10	CHK2
	Human	12.5% SDS-PAGE Stained with Coomassie Blue.	in vitro transl.
				Abnova Taiwan Corp.
H00011200-P01-25	CHK2
	Human	12.5% SDS-PAGE Stained with Coomassie Blue.	in vitro transl.
				Abnova Taiwan Corp.
H00011200-Q01-10	CHK2
	Human	12.5% SDS-PAGE Stained with Coomassie Blue
				Abnova Taiwan Corp.
H00011200-Q01-25	CHK2
	Human	12.5% SDS-PAGE Stained with Coomassie Blue
				Abnova Taiwan Corp.
P4196	CHK2
	Human
				Abnova Taiwan Corp.

Positive controls for CHK2 (4 products)

Catalog No.	Species
H00011200-T01	CHEK2 293T Cell Transient Overexpression Lysate(Denatured)

		Abnova Taiwan Corp.
LY416128	CHEK2 overexpression lysate
		0.1 mg / €295.00
		OriGene Technologies, Inc.
LY423638	CHEK2 overexpression lysate
		0.1 mg / €495.00
		OriGene Technologies, Inc.
NBL1-09147	Chk2 Lysate

		Novus Biologicals Inc.

Recommended Secondary Antibodies for CHK2 (11 products)

Catalog No.	Host	Pres.	Applications
R1253AP	Mouse IgG (H+L chain) antibody
	Rabbit	AP	C, E, WB
				OriGene Technologies GmbH
R1253B	Mouse IgG (H+L chain) antibody
	Rabbit	Biotin	C, E, WB
				OriGene Technologies GmbH
R1253F	Mouse IgG (H+L chain) antibody
	Rabbit	FITC	E, ICC/IF
				OriGene Technologies GmbH
R1253HRP	Mouse IgG (H+L chain) antibody
	Rabbit	HRP	C, E, WB
				OriGene Technologies GmbH
R1253TR	Mouse IgG (H+L chain) antibody
	Rabbit	Texas Red	ICC/IF
				OriGene Technologies GmbH
R1403R	Mouse IgG (H+L chain), F(ab)2 Fragment, adsorbed antibody
	Rabbit	PE	F
				OriGene Technologies GmbH
R1405R	Mouse IgG (H+L chain), F(ab)2 Fragment, adsorbed antibody
	Goat	PE
				OriGene Technologies GmbH
R1455R	Mouse IgG (H+L chain), F(ab)2 Fragment, adsorbed antibody
	Donkey	PE
				OriGene Technologies GmbH
R1457C2	Mouse IgG (H+L chain), adsorbed antibody
	Goat	Cy2
				OriGene Technologies GmbH
R1457C3	Mouse IgG (H+L chain), adsorbed antibody
	Goat	Cy3
				OriGene Technologies GmbH
R1457C5	Mouse IgG (H+L chain), adsorbed antibody
	Goat	Cy5
				OriGene Technologies GmbH

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