NB100-65030 Chondroitin Sulphate A+C antibody

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Mouse anti Human, Mammalia, Mouse, Rat Chondroitin Sulphate A+C CS-56


Product Description for Chondroitin Sulphate A+C

Mouse anti Human, Mammalia, Mouse, Rat Chondroitin Sulphate A+C CS-56.
Presentation: Ascites
Product is tested for Frozen Sections, Immunocytochemistry/Immunofluorescence, Paraffin Sections.

Properties for Chondroitin Sulphate A+C

Product Category Primary Antibodies
Quantity 0.1 ml
Synonyms chondroitin-4-sulfate, chondroitin-6-sulfate
Presentation Ascites
Reactivity Hu, Mam, Ms, Rt
Applications C, ICC/IF, P
Clonality Monoclonal
Clone CS-56
Host Mouse
Isotype IgM
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Ventral membranes of chicken gizzard fibroblasts.
Application immunofluorescence, Immunohistochemistry-Frozen, This antibody is useful for Immunohistochemistry-Frozen, immunofluorescence, immunofluorescence 1/100 - 1/400, Immunohistochemistry-Frozen 1/100 - 1/400
Background Many cellular activities depend on the interaction of cells with the surrounding extracellular matrix (ECM). Most cells, in intact tissue and in culture, are attached to an ECM. Epithelial cells are associated with the basement membrane; fibroblastic cells are usually embedded in a pericellular mesh of fibrils, and tissue culture cells usually grow on a substrate which is covered by various ECM components. Studies have indicated that the matrix or its various isolated components provide not only adhesive surfaces for cells to grow on but also have effects on the rate of cell growth, mobility, morphogenesis and differentiation. Within the ECM several glycoproteins and proteoglycans have been identified. It has been proposed that the different constituents interact with each other in a rather complex fashion. The poor antigenicity of proteoglycans especially their glycoaminoglycan (GAG) moieties make it difficult to localize these molecules in tissue and cell culture. Monoclonal Anti-Chondroitin Sulfate can be used to study chondroitin sulfate proteoglycan (CSPG) distribution and its relationships to specific cell-substrate contacts.
General Readings
  1. Avnur Z, Geiger B. Spatial interrelationships between proteoglycans and extracellular matrix proteins in cell cultures. Exp Cell Res. 1985 Jun;158(2):321-32. PubMed PMID: 3891385.
  2. Avnur Z, Geiger B. Immunocytochemical localization of native chondroitin-sulfate in tissues and cultured cells using specific monoclonal antibody. Cell. 1984 Oct;38(3):811-22. PubMed PMID: 6435883.
Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer System:
0.09% Sodium Azide
NB100-65030 reacts specifically with Chondroitin sulphate types A and C (not B, dermatan sulphate).It gives positive staining in bovine mammary gland epithelial cells, and also in human, chicken, and mouse fibroblast or tissues.
Human, Mammal, Mouse, Rat

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