NB120-11570 Chondroitin Sulphate A+C antibody

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Mouse anti Bovine, Chicken, Human, Mouse, Porcine, Rabbit, Rat Chondroitin Sulphate A+C CS-56


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  • NB120-11570
  • NB120-11570

Product Description for Chondroitin Sulphate A+C

Mouse anti Bovine, Chicken, Human, Mouse, Porcine, Rabbit, Rat Chondroitin Sulphate A+C CS-56.
Presentation: Ascites
Product is tested for Frozen Sections, Immunocytochemistry/Immunofluorescence, Paraffin Sections.

Properties for Chondroitin Sulphate A+C

Product Category Primary Antibodies
Quantity 0.1 ml
Synonyms chondroitin-4-sulfate, chondroitin-6-sulfate
Presentation Ascites
Reactivity Bov, Chk, Hu, Ms, Por, Rb, Rt
Applications C, ICC/IF, P
Clonality Monoclonal
Clone CS-56
Host Mouse
Isotype IgM
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Ventral membranes of chicken gizzard fibroblasts.
Application immunofluorescence, immunohistochemistry, This antibody is useful for immunofluorescence. This concentration was determined by indirect immunofluorescent labeling of BMGE cells. Good labeling may also be obtained with human, chicken and mouse fibroblasts or tissues. , immunohistochemistry , immunofluorescence 1:200
Background Many cellular activities depend on the interaction of cells with the surrounding extracellular matrix (ECM). Most cells, in intact tissue and in culture, are attached to an ECM. Epithelial cells are associated with the basement membrane; fibroblastic cells are usually embedded in a pericellular mesh of fibrils, and tissue culture cells usually grow on a substrate which is covered by various ECM components. Studies have indicated that the matrix or its various isolated components provide not only adhesive surfaces for cells to grow on but also have effects on the rate of cell growth, mobility, morphogenesis and differentiation. Within the ECM several glycoproteins and proteoglycans have been identified. It has been proposed that the different constituents interact with each other in a rather complex fashion. The poor antigenicity of proteoglycans especially their glycoaminoglycan (GAG) moieties make it difficult to localize these molecules in tissue and cell culture. Monoclonal Anti-Chondroitin Sulfate can be used to study chondroitin sulfate proteoglycan (CSPG) distribution and its relationships to specific cell-substrate contacts.
General Readings General / background references:Sobue M et al. Immunohistochemical techniques for detection of dermatan sulfate proteoglycan in tissue sections. Stain Technol 64:43-7 (1989). PubMed PMID: 2741184
Avnur Z & Geiger B Immunocytochemical localization of native chondroitin-sulfate in tissues and cultured cells using specific monoclonal antibody. Cell 38:811-22 (1984). PubMed PMID: 6435883
Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer System:
15mM Sodium Azide
The antibody has been reported to be specific for the glycosaminoglycan (GAG) portion of native chondroitin sulfate proteoglycan (CSPG). The antibody reacts specifically with chondroitin sulfate types A and C but not with type B (dermatan sulfate), and may be used for localization of chondroitin sulfate in tissues and cultured fibroblasts.
Bovine, Chicken, Human, Mouse

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