NB100-803 cIAP2 antibody

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Goat anti Human cIAP2


Product Description for cIAP2

Goat anti Human cIAP2.
Presentation: Aff - Purified
Product is tested for Western blot / Immunoblot.

Properties for cIAP2

Product Category Primary Antibodies
Quantity 0.1 mg
Presentation Aff - Purified
Reactivity Hu
Applications WB
Clonality Polyclonal
Host Goat
Isotype IgG
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Synthetic peptide with sequence CRSTIKGTVRT representing C-terminus of the human protein (residues 591-601) according to NP_001156.
Background Apoptosis can be inhibited by a group of proteins called inhibitors of apoptosis (IAPs). These proteins contain a BIR (baculovirus IAP repeat) domain near the amino-terminus. The BIR domain can bind some caspases. Many members of the IAP family of proteins block proteolytic activation of caspase-3 and ?7. For example, XIAP, cIAP 1 and cIAP 2 appear to block cytochrome c-induced activation of caspase-9, thereby preventing initiation of the caspase cascade. Since cIAP 1 and cIAP 2 were first identified as components in the cytosolic death domain-induced complex associated with the TNF family of receptors, they may inhibit apoptosis by additional mechanisms.
Concentration 0.5 mg/ml
General Readings Liston P et al. Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes. Nature 379:349-53 (1996). PubMed PMID: 8552191
Immunogen affinity purified
Buffer System:
Tris saline containing [pH7.3] with 0.5% BSA
Immunogen affinity purified
Aff - Purified
Cross-reacts with Human. Expected to cross-react with Rat and Mouse due to sequence homology. Not yet tested in other species.

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