discontinued

SP7045P CIDE A (aa. 200-214) antibody

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0.1 mg / €280.00

Quick Overview

Rabbit anti Mouse CIDE A

Product Description for CIDE A

Rabbit anti Mouse CIDE A.
Properties: (aa. 200-214)
Presentation: Purified
Product is tested for Western blot / Immunoblot.

Properties for CIDE A

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms CIDE-A, CIDEA, Cell Death-inducing DFFA-like Effector A
Presentation Purified
Reactivity Ms
Applications WB
Clonality Polyclonal
Host Rabbit
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Immunogen
Immunogen:
Rabbit anti-DR4 (NT) polyclonal antibody was raised against a peptide corresponding to amino acid 1 to 20 of human DR4 mature protein.
Property aa. 200-214
Application Western blot: 1/500 - 1/1000; A 57 kDa band should be observed.
Recommended Positive Control: HeLa
Background Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel death domain containing receptor was recently identified and designated DR4 (for death receptor 4) (1). The ligand for this novel death receptor has been identified and termed TRAIL (2,3), which is a new member in the TNF family. DR4 is also called TRAIL receptor-1 (TRAIL-R1) (4). DR4 is expressed in most of human tissues including spleen, peripheral blood leukocytes, small intestine and thymus. Like TNFR1, Fas and DR3, DR4 mediates apoptosis and NF-kB activation in many tissues and cells.
Concentration 0.5 mg/ml
General Readings
  1.  Pan G; O'Rourke K; Chinnaiyan AM; O'Rourke K; Gentz R; Ebner R; Ni J; Dixit VM. The receptor for the cytotoxic ligand TRAIL. Science; 1997;276:111-113.
  2. Wiley SR, Schooley K, Smolak PJ, Din WS, Huang CP, Nicholl JK, et al. Identification and characterization of a new member of the TNF family that induces apoptosis. Immunity. 1995 Dec;3(6):673-82. PubMed PMID: 8777713.
  3. Pitti RM, Marsters SA, Ruppert S, Donahue CJ, Moore A, Ashkenazi A. Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family. J Biol Chem. 1996 May 31;271(22):12687-90. PubMed PMID: 8663110.
  4.  Schneider P, Thome M, Burns K, Bodmer JL, Hofmann K, Kataoka T, Holler N, Tschopp J. TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-kB. Immunity 1997;7:831-836.
Storage

Store the antibody undiluted at 2-8°C.
Shelf life: one year from despatch.

Format
Purification:
Affinity chromatography on Protein G
Buffer System:
PBS
Preservatives:
0,02% sodium azide
State:
Liquid purified Ig fraction
Purified
Species Reactivity
Species reactivity (tested):
Human.
Specificity
Specificity:
This antibody reacts to DR4/TRAILR1 (NT).

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