SP6229P CIDE-B (205-219) antibody

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Rabbit anti Mouse CIDE-B (205-219)


Product Description for CIDE-B (205-219)

Rabbit anti Mouse CIDE-B (205-219).
Presentation: Aff - Purified
Product is tested for Western blot / Immunoblot.

Properties for CIDE-B (205-219)

Product Category Primary Antibodies
Quantity 50 µg
Presentation Aff - Purified
Reactivity Ms
Applications WB
Clonality Polyclonal
Host Rabbit
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer AnaSpec

Datasheet Extract

Rabbit anti-CIDE-B (CT) polyclonal antibody was raised against a peptide corresponding to amino acids 204 to 219 of murine CIDE-B (1).
Control Peptide available as SP6229P.
Application Western blot: 1/500 - 1/1000. Tissue lysate of murine liver can be used as positive control and an approximately 25 kDa band can be detected. Other applications not tested. Optimal dilutions of this antibody are dependent on conditions and should be determined by the user.
Concentration 0.5 µg/ml
General Readings 1. Inohara N et al (1998) CIDE, a novel family of cell death activators with homology to the 45 kDa subunit of the DNA fragmentation factor. EMBO J 17: 2526-33.
2. Inohara N et al (1999) Identification of regulatory and catalytic domains in the apoptosis nuclease DFF40/CAD. J Biol Chem 274: 270-4
Storage Store the antibody at 4-8°C for one month or at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Aff - Purified
This antibody recognises murine CIDE-B. It has no cross activity to CIDE-A.
Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase. DFF45/ICAD has been identified as inhibitor of caspase activated DNase DFF40/CAD. DFF45 related proteins CIDE-A and CIDE-B (for cell death-inducing DFF-like effector A and B) were recently identified (1). CIDE contains a new type of domain termed CIDE-N, which has high homology with the regulatory domains of DFF45/ICAD and DFF40/CAD (1,2). Expression of CIDE-B induces apoptosis, which is inhibited by DFF45. CIDE-B is a DFF45-inhibitable effector that promotes cell death and DNA fragmentation. CIDE-B is expressed mainly in liver and at lower levels in spleen, kidney, peripheral blood lymphocytes, and bone marrow (1).

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