NB300-1021 CIDE-B antibody

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Rabbit anti Mouse CIDE-B

Product Description for CIDE-B

Rabbit anti Mouse CIDE-B.
Presentation: Purified
Product is tested for Western blot / Immunoblot.

Properties for CIDE-B

Product Category Primary Antibodies
Quantity 0.05 mg
Presentation Purified
Reactivity Ms
Applications WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Synthetic peptide, corresponding to amino acids 204-219 of Mouse CIDE B.
Background Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase.DFF45/ICAD has been identified as inhibitor of caspase activated DNase DFF40/CAD. DFF45 related proteins CIDE-A (ab8402)and CIDE-B were recently identified. CIDE contains a new type of domain termed CIDE-N, which has high homology with the regulatory domains ofDFF45/ICAD and DFF40/CAD. Expression of CIDE-B induces apoptosis, which is inhibited by DFF45. CIDE-B isa DFF45-inhibitable effector that promotes cell death and DNA fragmentation. CIDE-B is expressed mainly in liver and at lower levels in spleen, kidney, peripheral blood lymphocytes, and bone marrow.
General Readings General / background references:Inohara N et al. Identification of regulatory and catalytic domains in the apoptosis nuclease DFF40/CAD. J Biol Chem 274:270-4 (1999). PubMed PMID: 9867840
Inohara N et al. CIDE, a novel family of cell death activators with homology to the 45 kDa subunit of the DNA fragmentation factor. EMBO J 17:2526-33 (1998). PubMed PMID: 9564035
IgG purified
Buffer System:
PBS with 0.02% sodium azide
IgG purified
Cross-reacts with Mouse. Not yet tested in other species.

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