Product Description for CLA
Rat anti Human, Mouse CLA HECA-452.
Presentation: FITC
Product is tested for Frozen Sections, Flow Cytometry, Paraffin Sections, Neutralisation.
Presentation: FITC
Product is tested for Frozen Sections, Flow Cytometry, Paraffin Sections, Neutralisation.
Properties for CLA
| Product Category | Primary Antibodies |
|---|---|
| Quantity | 100 Tests |
| Synonyms | Cutaneous lymphocyte-associated antigen |
| Presentation | FITC |
| Reactivity | Hu, Ms |
| Applications | C, F, NEUT, P |
| Clonality | Monoclonal |
| Clone | HECA-452 |
| Host | Rat |
| Isotype | IgM |
| Shipping to | Not USA/Canada |
| PDF datasheet | View Datasheet |
| Manufacturer | Novus Biologicals Inc. |
Datasheet Extract
| Add. information | Research Areas: Lipid and Metabolism |
|---|---|
| Application | flow cytometry / FACS analysis, Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is 20 microliter per million cells or 20 microliter per 100 microliter of whole blood. It is recommended that the reagent be titrated for optimal performance for each application., flow cytometry / FACS analysis |
| Background | Cutaneous Lymphocyte-assiciated Antigen (CLA) is a 140 kD homodimer protein recognized by a unique mAb HECA-452. It is expressed on T lymphocytes in skin, subsets of peripheral blood memory T cells, NK cells, memory B cells and dendritic cells, as well as on monocytes, granulocytes and activated endothelial cells. CLA is a carbohydrate epitope of sialic acid- and fucose-modified P-selectin glycoprotein ligand-1 (PSGL-1), a surface glycoprotein expressed on majority of peripheral blood leukocytes. CLA is a subset ligand for E-selectin, P-selectin, and L-selectin. It plays a role in memory lymphocyte homing, tethering and rolling. Treatment of activated HUVEC cells with HECA-452 antibody inhibits lymphocyte adhesion. The HECA-452 antibody is cross-reactive with mouse CLA, and is suitable for staining formalin-fixed paraffin embedded tissue sections. |
| General Readings |
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| Storage | Store at 4C. Do not freeze. |
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