CA257-100 CMV IE72 antibody

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0.1 mg / €360.00
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Quick Overview

Mouse anti CMV IE72 DF12

CA257-100

Product Description for CMV IE72

Mouse anti CMV IE72 DF12.
Presentation: Aff - Purified
Product is tested for Enzyme Immunoassay, Western blot / Immunoblot, Immunocytochemistry/Immunofluorescence.

Properties for CMV IE72

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms Cytomegalovirus Immediate Early Protein
Presentation Aff - Purified
Applications E, ICC/IF, WB
Clonality Monoclonal
Clone DF12
Host Mouse
Isotype IgG3
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Virusys Corporation

Datasheet Extract

Application Immunofluorescence: 1+ @ 1:800.
Western Blot: > 1:1,600. 
ELISA: 
0.100 @ 1:2,048.
Background Human Cytomegalovirus is a herpesvirus of  the betaherpesvirinae subfamily. The members of this subfamily tend to have a restricted host range, slow spread in cell culture and a long growth cycle as compared to Herpes Simplex Virus. CMV infected cells may become enlarged (cytomegalia), showing intranuclear inclusions. Co-survival of cell and virus is often established. Two recently recognized herpes viruses, HHV-6 and HHV-7, also belong to the betaherpesvirinae subfamily.

The virus is found universally throughout all geographic locations and socioeconomic groups and infects between 50 and 85% of adults in the United States by 40 years of age. CMV is also the virus most transmitted to a developing child before birth. The infection is more widespread in developing countries and in areas of lower socioeconomic conditions. For most healthy people who acquire the virus after birth, there are few symptoms and no long-term health consequences. Symptomatic experiences can include a mononucleosis-like syndrome with prolonged fever and a mild hepatitis. Once a person becomes infected, the virus remains viable but usually dormant in that person for life. For the vast majority of people, CMV infections are not a serious problem.

CMV infection is problematic to certain high-risk groups. These groups include (1) the unborn child (neonate) (2) people who work with children and (3) the immunocompromised, such as organ transplant patients and those infected with the human immunodeficiency virus (HIV). Neonates, infected in utero, may present with rashes, hepatitis, gastroenteritis and a range of organ specific maladies. With supportive treatment, most survive. However, in the first few years of life, 80-90% of the survivors will experience complications that may include hearing loss, vision impairment and varying degrees of mental retardation. CMV has also been associated with retinitis and increased mortality in patient groups undergoing immunosuppression due to organ transplant treatment or HIV infection.

Concentration 1 mg/ml
General Readings
  1. Jonathan P. Castillo, Timothy F. Kowalik. Human cytomegalovirus immediate early proteins and cell growth control. Gene 290 (2002) 19-34.
Format
Buffer System:
Phosphate Buffered Saline (PBS) pH 7.4
State:
Affinity Purified, > 95% IgG by SDS-PAGE
Aff - Purified
Specificity
Specificity:
Cytomegalovirus Immediate Early Protein.

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