GTX19811 Collagen type I antibody

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0.1 mg / €350.00

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Goat anti Human Collagen type I


Product Description for Collagen type I

Goat anti Human Collagen type I.
Presentation: Aff - Purified
Product is tested for Frozen Sections, Dot blot, Enzyme Immunoassay, Immunocytochemistry/Immunofluorescence.

Properties for Collagen type I

Product Category Primary Antibodies
Quantity 0.1 mg
Presentation Aff - Purified
Reactivity Hu
Applications C, Dot, E, ICC/IF
Clonality Polyclonal
Host Goat
Isotype IgG
Shipping to Europe only
PDF datasheet View Datasheet
Manufacturer GeneTex Inc.

Datasheet Extract

Full length native protein (purified) (Human).
Application Dot, ELISA, ICC, IHC-Fr
Background Collagens are highly conserved throughout evolution and are characterised by an uninterrupted "Glycine X Y" triplet repeat that is a necessary part of the triple helical structure. For these reasons it is often extremely difficult to generate antibodies with specificities to collagens. The development of type specific antibodies is dependent on NON DENATURED three dimensional epitopes. This preparation results in a native conformation of the protein.Type I collagen (95 kDa) is found in bone, cornea, skin and tendon.Mutations in the gene encoding collagen 1 are associated with osteogenesis imperfecta, Ehlers Danlos syndrome, and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.
Concentration 0.4 mg/ml
Storage Keep as concentrated solution. Store at 4
Immunogen affinity purified
Buffer System:
Preservative: None. Constituents: 100mM Borate buffered saline. pH 8
Immunogen affinity purified
Aff - Purified
Human - Not yet tested in other species

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