NB110-4130 Collagen, type I antibody

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Mouse anti Human Collagen, type I BDI314


Product Description for Collagen, type I

Mouse anti Human Collagen, type I BDI314.
Presentation: Ascites
Product is tested for Enzyme Immunoassay, Western blot / Immunoblot, Paraffin Sections.

Properties for Collagen, type I

Product Category Primary Antibodies
Quantity 0.1 mg
Presentation Ascites
Reactivity Hu
Applications E, P, WB
Clonality Monoclonal
Clone BDI314
Host Mouse
Isotype IgG1
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Background Collagens are highly conserved throughout evolution and are characterised by an uninterrupted Glycine X Y; triplet repeat that is a necessary part of the triple helical structure. For these reasons it is often extremely difficult to generate antibodies with specificities to collagens. The development of type specific antibodies is dependent on NON DENATURED three dimensional epitopes. This preparation results in a native conformation of the protein.
Type I collagen (95 kDa) is found in bone, cornea, skin and tendon.
Mutations in the gene encoding collagen 1 are associated with osteogenesis imperfecta, Ehlers Danlos syndrome, and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.
Concentration 1 mg/ml
General Readings British Journal of Haematology, 90:757-766 (1995)
This antibody reacts with human proteins. No other species have been tested.

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