NB100-2728 Collagen Type VII antibody

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Mouse anti Porcine Collagen Type VII LH7.2


Product Description for Collagen Type VII

Mouse anti Porcine Collagen Type VII LH7.2.
Product is tested for Frozen Sections, Paraffin Sections.

Properties for Collagen Type VII

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms VII
Reactivity Por
Applications C, P
Clonality Monoclonal
Clone LH7.2
Host Mouse
Isotype IgG1
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Crude extract of skin
Add. information Research Areas: Cancer
Application Immunohistochemistry-Frozen, Immunohistology - Frozen; suggested working dilution: 1/5- 1/10., Immunohistochemistry-Frozen
Background Type VII collagen fibrils are composed of three identical alpha collagen chains. It's location is restricted to the basement zone beneath stratified squamous epithelia. It functions as an anchoring fibril between the external epithelia and the underlying stroma. Mutations in the collagen V11 gene are associated with all forms of dystrophic epidermolysis bullosa.
General Readings This product has been used in:Kirkham N et al. Type VII collagen antibody LH 7.2 identifies basement membrane characteristics of thin malignant melanomas. J Pathol 157:243-7 (1989). PubMed PMID: 2647941
Heagerty AH et al. Identification of an epidermal basement membrane defect in recessive forms of dystrophic epidermolysis bullosa by LH 7:2 monoclonal antibody: use in diagnosis. Br J Dermatol 115:125-31 (1986). PubMed PMID: 3527251
General / background references:Leigh IM Epithelia 1987:17-29 (0).
Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Tissue culture supernatant
Buffer System:
No Preservative
Tissue culture supernatant
Recognizes the carboxyterminus of type VII collagen.
Mouse (-), Porcine

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