NBP1-05120 Complement SC5b-9 (TCC / MAC) antibody

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0.1 mg / €450.00
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Mouse anti Equine, Human, Porcine, Baboon Complement SC5b-9 (TCC / MAC)

NBP1-05120

Product Description for Complement SC5b-9 (TCC / MAC)

Mouse anti Equine, Human, Porcine, Baboon Complement SC5b-9 (TCC / MAC).
Presentation: Purified
Product is tested for Frozen Sections, Enzyme Immunoassay, Paraffin Sections.

Properties for Complement SC5b-9 (TCC / MAC)

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms Membrane attack complex, Terminal complement complex
Presentation Purified
Reactivity Bab, Eq, Hu, Por
Applications C, E, P
Clonality Polyclonal
Host Mouse
Isotype IgG2a
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Immunogen
Immunogen:
Purified C5b-9
Application ELISA, immunohistochemistry, ELISA and Immunohistochemistry, ELISA , immunohistochemistry ,
Background C5b-9 is also known as the terminal complement complex (TCC). The TCC consists of C5b, C6, C7, C8 and C9 and forms the membrane attack complex (MAC) as well as the non-lytic fluid-phase SC5b-9 complex (with protein S). The MAC forms channels in target cell membranes leading to cell lysis by osmotic leakage. The complexes contain neoantigens that are absent from the individual native components from which they are formed and this antibody is directed against a neoepitope exposed on C9 when incorporated into the TCC (1,2).
Concentration 1 mg/ml
General Readings
  1. Mollnes TE, Lea T, Harboe M, Tschopp J. Monoclonal antibodies recognizing a neoantigen of poly(C9) detect the human terminal complement complex in tissue and plasma. Scand J Immunol. 1985 Aug;22(2):183-95. PubMed PMID: 4035298.
  2. Drogari-Apiranthitou M, Kuijper EJ, Dekker N, Dankert J. Complement activation and formation of the membrane attack complex on serogroup B Neisseria meningitidis in the presence or absence of serum bactericidal activity. Infect Immun. 2002 Jul;70(7):3752-8. PubMed PMID: 12065518. (Free PMC Article available, 5 images available)
  3. Jansen JH, Høgåsen K, Mollnes TE. Extensive complement activation in hereditary porcine membranoproliferative glomerulonephritis type II (porcine dense deposit disease). Am J Pathol. 1993 Nov;143(5):1356-65. PubMed PMID: 8238252. (Free PMC Article available)
  4. Mollnes TE, Lea T, Frøland SS, Harboe M. Quantification of the terminal complement complex in human plasma by an enzyme-linked immunosorbent assay based on monoclonal antibodies against a neoantigen of the complex. Scand J Immunol. 1985 Aug;22(2):197-202. PubMed PMID: 2412280.
  5. Mollnes TE (1997) Analysis of in vivo complement activation. Herzenberg LA, Weir DM, Herzenberg LA, Blackwell C: Weir's Handbook of Experimental Immunology. Boston, MA: Blackwell Science, pp. 78.1-78.8.
Storage Store at 4C. Do not freeze.
Format
Purification:
protein A purified
Buffer System:
0.09% Sodium Azide
Purity:
protein A purified
State:
Purified
Specificity
Specificity:
Binds both membrane-bound MAC and fluid phase SC5b-9 complexes.
Species:
Baboon, Equine, Human, Porcine

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