TA332428 COPS5 antibody

Rabbit anti-COPS5 Polyclonal Antibody

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0.1 mg / €335.00
Please visit the country specific website of OriGene Technologies or contact your local Distributor to buy this product.

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Rabbit anti Human, Mouse, Rat COPS5

TA332428

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Product Description for COPS5

Rabbit anti Human, Mouse, Rat COPS5.
Presentation: Purified

Properties for COPS5

Product Category Primary Antibodies
Target Category
Quantity 0.1 mg
Synonyms COP9 signalosome complex subunit 5, CSN5, JAB1, Jun activation domain-binding protein 1, SGN5, Signalosome subunit 5
Presentation Purified
Reactivity Hu, Ms, Rt
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Europe, USA/Canada
PDF datasheet View Datasheet
Manufacturer OriGene Technologies, Inc.

Datasheet Extract

Immunogen
Swiss Prot Num:
Q92905
Immunogen:
Recombinant protein of human COPS5.
GeneID:
10987
Application WB 1:500 - 1:2000
IHC 1:50- 1:200
Background The COP9 Siglosome (CSN) is a ubiquitously expressed multiprotein complex that is involved in a vast array of cellular and developmental processes, which is thought to be attributed to its control over the ubiquitin-proteasome pathway. Typically, the CSN is composed of eight highly conserved subunits (CSN1-CSN8), each of which is homologous to one of the eight subunits that form the lid of the 26S proteasome particle, suggesting that these complexes have a common evolutiory ancestor (1). CSN was first identified in Arabidopsis thalia mutants with a light-grown seedling phenotype when grown in the dark (2-4). The subsequent cloning of the constitutive morphogenesis 9 (cop9) mutant from Arabidopsis thalia was soon followed by the biochemical purification of the COP9-containing multiprotein complex (4). It is now widely accepted that the CSN directly interacts with cullin-RING ligase (CRL) families of ubiquitin E3 complexes, and that CSN is required for their proper function (5). In addition, CSN may also regulate protein homeostasis through its association with protein kises and deubiquititing enzymes. Collectively, these activities position the CSN as a pivotal regulator of the D-damage response, cell-cycle control, and gene expression (1).
Format
Purification:
Affinity purification
Buffer System:
Store at -20°C (regular) and -80°C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
State:
Purified

Accessory Products

Proteins and/or Positive Controls

Proteins for COPS5 (3 products)

Catalog No. Species Pres. Purity   Source  

COPS5

COPS5 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

COPS5

COPS5 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

COPS5

COPS5 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

Positive controls for COPS5 (1 products)

Catalog No. Species Pres. Purity   Source  

JAB1 Lysate

Western Blot: JAB1 Lysate [NBL1-09383] - Western Blot experiments.  Left-Control; Right -Over-expression Lysate for COPS5.
  Novus Biologicals Inc.
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