discontinued

NB100-63135 CRIT antibody

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0.1 mg / €430.00

Quick Overview

Human anti Human CRIT 4644

Product Description for CRIT

Human anti Human CRIT 4644.
Presentation: Aff - Purified
Product is tested for Enzyme Immunoassay, Western blot / Immunoblot.

Properties for CRIT

Product Category Primary Antibodies
Quantity 0.1 mg
Presentation Aff - Purified
Reactivity Hu
Applications E, WB
Clonality Monoclonal
Clone 4644
Host Human
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Immunogen
Immunogen:
Synthetic peptide derived from the first 27 amino acids of the first extracellular domain of human CRIT conjugated to BSA and Transferrin (MSPSLVSYTQKNERGSHEVKIKHFSPY)
Application ELISA, Western Blot, This antibody is useful for ELISA, Western Blot, ELISA Western Blot
Concentration 1 mg/ml
General Readings
  1. Inal JM, Hui KM, Miot S, Lange S, Ramirez MI, Schneider B, et al. Complement C2 receptor inhibitor trispanning: a novel human complement inhibitory receptor. J Immunol. 2005 Jan 1;174(1):356-66. PubMed PMID: 15611259.
Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Format
Purification:
Affinity purified
Buffer System:
Sodium Azide
Purity:
Affinity purified
State:
Aff - Purified
Specificity
Specificity:
NB100-63135 recognizes the novel human complement regulatory cell surface receptor designated CRIT (Complement C2 receptor inhibitor trispanning). CRIT binds complement factor C2 and blocks the classical pathway of complement activation. CRIT protein expression has been specifcally identified by immunohistochemistry in podocyte cells in human kidney glomeruli, and is also expressed on hematopoietic cells and a range of other human tissues. CRIT appears to function as a regulatory molecule protecting autologous cells from damage by complement. Expression has also been demonstrated by human parasites, which have acquired CRIT by horizontal transmission.
Species:
Human

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