AP05218PU-N CRMP1 (CT) antibody

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Rabbit anti Human, Mouse, Rat CRMP1 (CT)

Product Description for CRMP1 (CT)

Rabbit anti Human, Mouse, Rat CRMP1 (CT).
Presentation: Aff - Purified
Product is tested for Western blot / Immunoblot.

Properties for CRMP1 (CT)

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms Collapsin response mediator protein 1 / DRP-1 / dihydropyropyrimidinase-related protein 1
Presentation Aff - Purified
Reactivity Hu, Ms, Rt
Applications WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Rabbit polyclonal CRMP1 antibody was raised against a 15 amino acid peptide from near the carboxy terminus of human CRMP1.
Application Western Blot: 0,5 - 1 µg/ml; 3T3 cell lysate can be used as positive control.
Background Collapsin-response mediator proteins (CRMPs) are highly expressed in the developing brain where they play major roles in axonal outgrowth, neurite differentiation, and apoptosis (1). Their continued expression in areas of high synaptic remodeling such as the cerebellum, hippocampus, and the olfactory system suggests that these proteins may also be involved in adult brain plasticity (2). CRMP-1 was initially identified as a dihydro-pyrimidinase expressed exclusively in brain (3); later studies have shown that it is involved with neurotrophin (NT) 3-induced neurite formation and outgrowth (4). CRMP-1 localization switches from axonal to somatodendritic when neurons reach functional maturity, suggesting that it is involved in early neuronal differentiation as well as in later processes related to the survival or death of the newly generated neurons (5).
Concentration Lot specific
General Readings
  1. Charrier E, Reibel S, Rogemond V, et al. Collapsin response mediator proteins (CRMPs): involvement in nervous system development and adult neurodegenerative disorders. Mol. Neurobiol. 2003; 28:51 - 64.
  2. Cameron HA and McKay RD. Adult neurogenesis produces a large pool of new granule cells in the dentate gyrus. J. Comp. Neurol. 2001; 435:406 - 417.
  3. Hamajima N, Matsuda K, Sakata S, et al. A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution.Gene. 1996; 180:157 - 63.
  4. Quach TT, Duchemin A-M, Rogemond V, et al. Involvement of collapsin response mediator proteins in the neurite extension induced by neurotrophins in dorsal root ganglion neurons. Mol. Cell Neurosci. 2004; 25:433 - 43.
Storage The antibody can be shipped at ambient temperature. Store (in aliquots) at -20°C only.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Buffer System:
Phosphate buffered saline with 0.02% sodium azide
Aff - Purified
Liquid purified Ig
Aff - Purified
This antibody reacts to CRMP1 (CT).
Human, Mouse, Rat.

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