NBP1-22593 Cytokeratin 10 (LHP1) antibody

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Mouse anti Human Cytokeratin 10 (LHP1) LHP1


Product Description for Cytokeratin 10 (LHP1)

Mouse anti Human Cytokeratin 10 (LHP1) LHP1.
Presentation: Purified
Product is tested for Paraffin Sections.

Properties for Cytokeratin 10 (LHP1)

Product Category Primary Antibodies
Quantity 0.5 ml
Synonyms anti-CK 10 antibody, anti-CK10 antibody, anti-Cytokeratin 10 antibody, anti-Cytokeratin10 antibody, anti-KPP antibody, anti-KRT10 antibody, anti-Keratin 10 antibody, anti-Keratin type I cytoskeletal 10 antibody, anti-Keratin type I cytoskeletal 59 kDa antibody, anti-Keratin10 antibody, anti-Krt 10 antibody, anti-k10 antibody, anti-krt10 antibody
Presentation Purified
Reactivity Hu
Applications P
Clonality Monoclonal
Clone LHP1
Host Mouse
Isotype IgG1
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Crude cytoskeletal extract prepared from the epidermal component of trypsin-split normal adult skin.
Isotype control AM03095PU-N, SM10P (for use in human samples)
Application immunohistochemistry, ABC, immunohistochemistry 1:25-1:50
Background Cytokeratin 10 is a heterotetramer of two type I and two type II keratins. Cytokeratin 10 is generally associated with keratin 1. It is seen in all suprabasal cell layers including stratum corneum. A number of alleles are known that mainly differ in the Gly-rich region (positions 490-560). Defects in cytokeratin 10 are a cause of epidermolytic hyperkeratosis (EHK), also known as bullous congenital ichthyosiform erythroderma (BCIE) or bullous erythroderma ichthyosiformis congenita of Brocq. EHK is an hereditary skin disorder characterized by blistering and a marked thickening of the stratum corneum. At birth, affected individuals usually present with redness, blisters and superficial erosions due to cytolysis. Within a few weeks, the erythroderma and blister formation diminish and hyperkeratoses develop. Transmission is autosomal dominant, but most cases are sporadic. Defects in cytokeratin 10 are also a cause of annular epidermolytic ichthyosis (AEI), also known as cyclic ichthyosis with epidermolytic hyperkeratosis. AEI resembles clinical and histologic features of both epidermolytic hyperkeratosis and ichthyosis bullosa of Siemens.
Storage Store at 4C. Do not freeze.
IgG purified
Buffer System:
Sodium Azide
IgG purified
This antibody is specific to human cytokeratin 10. It recognizes a 56.5 kD cytokeratin protein and is found in suprabasal layers of keratinizing stratified epithelia, suprabasal layers of non-keratinizing stratified epithelia and in differentiated areas of squamous carcinomas. This antibody is useful in the differentiation of stratified squamous epithelia.

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