NBP1-22746 Cytokeratin 16 (LL025) antibody

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Mouse anti Human Cytokeratin 16 (LL025) LL025

Product Description for Cytokeratin 16 (LL025)

Mouse anti Human Cytokeratin 16 (LL025) LL025.
Presentation: Purified
Product is tested for Paraffin Sections.

Properties for Cytokeratin 16 (LL025)

Product Category Primary Antibodies
Quantity 0.5 ml
Synonyms anti-CK 16 antibody, anti-CK16 antibody, anti-Cytokeratin16 antibody, anti-Focal non epidermolytic palmoplantar keratode, anti-K 16 antibody, anti-K16 antibody, anti-K1CP antibody, anti-KRT 16 antibody, anti-KRT16 antibody, anti-KRT16A antibody, anti-Keratin 16 antibody, anti-Keratin type I cytoskeletal 16 antibody, anti-Keratin16 antibody, anti-NEPPK antibody
Presentation Purified
Reactivity Hu
Applications P
Clonality Monoclonal
Clone LL025
Host Mouse
Isotype IgG1
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

BALB/C mice were injected with a synthetic peptide from the C-terminus of human cytokeratin 16.
Isotype control AM03095PU-N, SM10P (for use in human samples)
Application immunohistochemistry, ABC, immunohistochemistry 1:25-1:75
Background Keratin 16 is expressed in keratinocytes, which are undergoing rapid turnover in the suprabasal region (also known as hyperproliferation-related keratins). Keratin 16 is absent in normal breast tissue and in noninvasive breast carcinomas. Only 10% of the invasive breast carcinomas show diffuse or focal positivity. Reportedly, a relatively high concordance was found between the carcinomas immunostaining with the basal cell and the hyperproliferation-related keratins, but not between these markers and the proliferation marker Ki-67. This supports the conclusion that basal cells in breast cancer may show extensive proliferation, and that absence of Ki-67 staining does not mean that (tumor) cells are not proliferating. Two cytokeratins, 6 and 16, are expressed when keratincytes are undergoing rapid turnover in various pathological states, wound healing, psoriasis and some carcinomas
Storage Store at 4C. Do not freeze.
IgG purified
Buffer System:
Sodium Azide
IgG purified
This antibody is specific to a 48 kD protein, identified as cytokeratin 16. Cytokeratin 16 is expressed in keratinocytes which undergop rapid turnover in the suprabasal region. High concordance was found between the carcinomas immunostaining with the basal cell and the hyper proliferation related keratins.

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