AP31679SU-N Cytokeratin 40 antibody

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0.1 ml / €360.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

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Guinea Pig anti Human Cytokeratin 40

AP31679SU-N

Product Description for Cytokeratin 40

Guinea Pig anti Human Cytokeratin 40.
Presentation: Serum
Product is tested for Frozen Sections, Immunocytochemistry/Immunofluorescence, Paraffin Sections.

Properties for Cytokeratin 40

Product Category Primary Antibodies
Quantity 0.1 ml
Synonyms CK-40, K40, KA36, KRT40, Keratin, Keratin 40, Keratin-40, Keratin40, Type I hair keratin Ka36, type I cytoskeletal 40
Presentation Serum
Reactivity Hu
Applications C, ICC/IF, P
Clonality Polyclonal
Host Guinea Pig
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
Q6A162
Immunogen:
Synthetic peptide of human type I (acidic) hair (trichocytic) keratin K40 (former designation keratin Ka36) coupled to KLH
AA Sequence:
LPC YFT GSC NSP C
GeneID:
125115
Application Immunofluorescence Microscopy on Frozen Sections.
Immunohistochemistry on Paraffin Sections
Only when using the microwave method (with citrate buffer).
Working Dilution: 1/100 for Immunohistochemistry.
Incubation Time: 1h at RT.
Note: For enhancement of staining preincubate fixed sections with 0.1 Triton X-100 (in PBS) for 1–5 min prior to first antibody incubation step.
Background Keratin 40 (KRT40), also known as Cytokeratin-40 (CK-40) or KA36, is a 431 amino acid protein that belongs to the intermediate filament family. As a heterotetramer of two type I and two type II keratins, Keratin 40 may play a role in late hair differentiation. While weakly expressed in tongue, breast, colon and small intestine, Keratin 40 is highly expressed in skin and scalp. The gene that encodes Keratin 40 consists of approximately 9,420 bases and maps to human chromosome 17q21.2. Encoding more than 1,200 genes, chromosome 17 comprises over 2.5% of the human genome. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of ovary, colon, prostate gland and fallopian tubes.
General Readings
  1. Langbein L, Rogers MA, Praetzel-Wunder S, Boeckler D, Schirmacher P, Schweizer J: The novel keratins K39 and K40 are the latest expressed type II hair keratins and complete the human hair keratin family. J Invest Dermatol 127, 1532-1535 (2007)
Storage Store the antibody undiluted at 2-8°C.
Shelf life: one year from despatch.
Format
State:
Stabilized antiserum containing 0.09% Sodium Azide as preservative
Serum
Specificity
Specificity:
The antiserum stains specifically Human type I (acidic) hair Keratin K40 expressed in the late hair cuticle.
Species:
Human. Negative with Mouse.
Gene ID 125115

Accessory Products

Proteins and/or Positive Controls

Positive controls for Cytokeratin 40 (1 products)

Catalog No. Species Pres. Purity   Source  

KRT40 overexpression lysate

KRT40 overexpression lysate
0.1 mg / €280.00
  OriGene Technologies, Inc.
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