DM051 Cytokeratin 5+6+18 antibody

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1 ml / €490.00
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Mouse anti Bovine, Human, Rat Cytokeratin 5+6+18 LP34

Product Description for Cytokeratin 5+6+18

Mouse anti Bovine, Human, Rat Cytokeratin 5+6+18 LP34.
Presentation: Supernatant
Product is tested for Paraffin Sections.

Properties for Cytokeratin 5+6+18

Product Category Primary Antibodies
Quantity 1 ml
Synonyms CK18, CK5, CK6, Cytokeratin 18, Cytokeratin 6, K18, K5, K6, KRT-5, KRT-6, KRT-8, KRT5, KRT6, KRT8, Keratin, type I cytoskeletal 18, type II cytoskeletal 5, type II cytoskeletal 6
Presentation Supernatant
Reactivity Bov, Hu, Rt
Applications P
Clonality Monoclonal
Clone LP34
Host Mouse
Isotype IgG1
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Human Keratin
Application Immunohistochemistry on Formalin-Fixed Paraffin Embedded Tissus: Use a dilution of 1/25-1/50 in an ABC method (30 minutes at room temperature).
Enzymatic predigestion of paraffin embedded tissues is recommended prior to the immunostaining.
Recommended Positive Control: Skin
Background Cytokeratins, a group of at least 29 different proteins, are characteristic of epithelial and trichocytic cells. Cytokeratins 4, 5, 6 and 8 are members of the type II neutral-to-basic subfamily. Cytokeratin peptide 4 (59 kDa) is the secondary type II keratin expressed in non cornified stratified squamous epithelia. Cytokeratin peptide 5 (58 kDa) is the primary type II keratin in stratified epithelia, while cytokeratin type 8 (52 kDa) is a major type II keratin in simple epithelia. Cytokeratin 6 (56 kDa) is a "hyperproliferation" cytokeratin expressed in tissues with natural or pathological high turnover. Cytokeratins 10, 13 and 18 are members of the type I acidic subfamily. Cytokeratin peptide 10 (56 kDa) is the secondary type I keratin expressed in cornified epithelia. Cytokeratin 13 (54 kDa) is the secondary type I keratin expressed in non-cornified stratified squamous epithelia. Cytokeratin 18 (45 kDa) is the primary type I keratin expressed in simple epithelial cells.
General Readings
  1. Gatter et al. J Clin Pathol 35: 1253, 1982.
  2. Gosh et al. Br J Haematol 61: 21, 1985.
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Purified antibody containing Sodium Azide as preservative
This antibody is of value in the identification of tumor cells as being of epithelial or less commonly of mesothelial origin. It recognizes keratin polypeptide of 45 (keratin 5), 56 (keratin 6) and 58 kD (keratin 18).
It shows a broad pattern of reactivity with epithelial tissues from simple glandular epithelia to stratified squamous epithelia.
Cellular Localization: Cytoplasmic
Human, Bovine and Rat.
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