NB100-65113 Cytokeratin 5+6+18 antibody

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Mouse anti Human Cytokeratin 5+6+18 LP34


Product Description for Cytokeratin 5+6+18

Mouse anti Human Cytokeratin 5+6+18 LP34.
Presentation: Supernatant
Product is tested for Frozen Sections, Paraffin Sections.

Properties for Cytokeratin 5+6+18

Product Category Primary Antibodies
Quantity 1 ml
Synonyms CK18, CK5, CK6, Cytokeratin 18, Cytokeratin 6, K18, K5, K6, KRT-5, KRT-6, KRT-8, KRT5, KRT6, KRT8, Keratin type I cytoskeletal 18, Keratin type II cytoskeletal 5, Keratin type II cytoskeletal 6
Presentation Supernatant
Reactivity Hu
Applications C, P
Clonality Monoclonal
Clone LP34
Host Mouse
Isotype IgG1
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Detergent-insoluble fraction of psoriatic human epidermis
Application Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin This product requires protein digestion pre-treatment of paraffin sections e.g. trypsin. In frozen sections this antibody recognizes cytokeratin 5, 6 and 18 with equal intensity, but staining of cytokeratin 18 in paraffin-embedded tissues may be variable., Immunohistochemistry-Paraffin 1:100, Immunohistochemistry-Frozen 1:100
Background Cytokeratins, a group of at least 29 different proteins, are characteristic of epithelial and trichocytic cells. Cytokeratins 4, 5, 6 and 8 are members of the type II neutral-to-basic subfamily. Cytokeratin peptide 4 (59 kDa) is the secondary type II keratin expressed in non cornified stratified squamous epithelia. Cytokeratin peptide 5 (58 kDa) is the primary type II keratin in stratified epithelia, while cytokeratin type 8 (52 kDa) is a major type II keratin in simple epithelia. Cytokeratin 6 (56 kDa) is a "hyperproliferation" cytokeratin expressed in tissues with natural or pathological high turnover. Cytokeratins 10, 13 and 18 are members of the type I acidic subfamily. Cytokeratin peptide 10 (56 kDa) is the secondary type I keratin expressed in cornified epithelia. Cytokeratin 13 (54 kDa) is the secondary type I keratin expressed in non-cornified stratified squamous epithelia. Cytokeratin 18 (45 kDa) is the primary type I keratin expressed in simple epithelial cells. Cytokeratin is a heterotetramer of two type I and two type II keratins. Keratin 1 is generally associated with keratin 10. Defects in Cytokeratin are a cause of epidermolytic hyperkeratosis, also known as bullous congenital ichthyosiform erythroderma (BIE), which is a hereditary skin disorder characterized by blistering and a marked thickening of the stratum corneum. Defects in Cytokeratin are also the cause of Curth Macklin type ichthyosis hystrix, nonepidermolytic palmoplantar keratoderma, annular epidermolytic ichthyosis and keratosis palmoplantaris striata III (PPKS3). PPKS3 is an autosomal dominant disorder affecting palm and sole skin where stratum corneum and epidermal layers are thickened. There is no involvement of nonpalmoplantar skin, and both hair and nails are normal.
Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Tissue culture supernatant
Buffer System:
15mM Sodium Azide
Tissue culture supernatant
Recognizes human cytokeratins 5, 6 and 18. The has a broad reactivity with epithelial tissues ranging from simple glandular epithelial to stratified squamous epithelial. This reagent is valuable for the identification of epithelial tumors.
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