NBP1-22533 Cytokeratin 5+6+18 antibody

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0.5 ml / €400.00
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Mouse anti Human Cytokeratin 5+6+18 LP34

Product Description for Cytokeratin 5+6+18

Mouse anti Human Cytokeratin 5+6+18 LP34.
Presentation: Purified
Product is tested for Paraffin Sections.

Properties for Cytokeratin 5+6+18

Product Category Primary Antibodies
Quantity 0.5 ml
Synonyms CK18, CK5, CK6, Cytokeratin 18, Cytokeratin 6, K18, K5, K6, KRT-5, KRT-6, KRT-8, KRT5, KRT6, KRT8
Presentation Purified
Reactivity Hu
Applications P
Clonality Monoclonal
Clone LP34
Host Mouse
Isotype IgG1
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

BALB/C mice were immunized with human Keratin.
Application immunohistochemistry, ABC, immunohistochemistry 1:25-1:50
Background Cytokeratins, a group of at least 29 different proteins, are characteristic of epithelial and trichocytic cells. Cytokeratins 4, 5, 6 and 8 are members of the type II neutral-to-basic subfamily. Cytokeratin peptide 4 (59 kDa) is the secondary type II keratin expressed in non cornified stratified squamous epithelia. Cytokeratin peptide 5 (58 kDa) is the primary type II keratin in stratified epithelia, while cytokeratin type 8 (52 kDa) is a major type II keratin in simple epithelia. Cytokeratin 6 (56 kDa) is a "hyperproliferation" cytokeratin expressed in tissues with natural or pathological high turnover. Cytokeratins 10, 13 and 18 are members of the type I acidic subfamily. Cytokeratin peptide 10 (56 kDa) is the secondary type I keratin expressed in cornified epithelia. Cytokeratin 13 (54 kDa) is the secondary type I keratin expressed in non-cornified stratified squamous epithelia. Cytokeratin 18 (45 kDa) is the primary type I keratin expressed in simple epithelial cells. Monoclonal anti-cytokeratins are specific markers of epithelial cell differentiation and have been widely used as tools in tumor identification and classification. Monoclonal [C-11] to Cytokeratin may be used for staining of cultured epithelial cell lines. It also facilitates typing of normal, metaplastic and neoplastic cells and may aid in the discrimination of carcinomas and non-epithelial tumors such as sarcomas, lymphomas and neural tumors. In addition, it is useful in detecting micrometastases in lymph nodes, bone marrow and other tissues and for determining the origin of poorly differentiated tumors.
Storage Store at 4C. Do not freeze.
IgG purified
Buffer System:
Sodium Azide
IgG purified
This antibody recognizes keratin polypeptide of 45 (keratin 5), 56 (keratin 6) and 58 kD (keratin 18). It shows a broad pattern of reactivity with human epithelial tissues from simple glandular epithelia to stratified squamous epithelia. This antibody is of value in the identification of tumor cells as being of epithelial or less commonly of mesothelial origin.
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