discontinued

NB100-2776 Cytokeratin 7, 13, 17, 18 antibody

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0.1 mg / €340.00

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Mouse anti Human Cytokeratin 7, 13, 17, 18 LdS 23

NB100-2776

Product Description for Cytokeratin 7, 13, 17, 18

Mouse anti Human Cytokeratin 7, 13, 17, 18 LdS 23.
Presentation: Purified
Product is tested for Frozen Sections, Paraffin Sections, Western blot / Immunoblot.

Properties for Cytokeratin 7, 13, 17, 18

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms KRT13, KRT17, KRT18, KRT7
Presentation Purified
Reactivity Hu
Applications C, P, WB
Clonality Monoclonal
Clone LdS 23
Host Mouse
Isotype IgG1
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Immunogen
Immunogen:
Cytoskeletons of the human urothelial RT4 cell line
Isotype control AM03095PU-N, SM10P (for use in human samples)
Application immunohistochemistry, Immunohistochemistry-Frozen, Western Blot, Immunohistochemistry-Frozen and Western Blot, immunohistochemistry Assay dependent, Western Blot Assay dependent, Immunohistochemistry-Frozen Assay dependent
Background Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue- and differentiation-specific expression profiles. Keratins 7 and 8 are two closely related type II keratins characteristic of simple epithelia. Keratin 7 is less widespread than keratin 8 and is expressed in sebaceous and sweat glands and some cells of the inner hair root sheath. Keratin 7 is often co-expressed with keratin 19. Keratin 17 is expressed in suprabasal keratinocytes of wounded epidermis. Keratins 8 and 18 are two of the first keratins expressed in the embryo, and persist into adult tissues as the keratin pair representing minimal epithelial keratin expression. Keratins 8 and 18 are major components of all simple epithelia (but not of stratified squamous epithelia) and adenocarcinomas. LdS 23 is useful for studies of epithelial cells and tumour origin.
Concentration 1 mg/ml
General Readings General / background references:Southgate J et al. Primary culture of human oral epithelial cells. Growth requirements and expression of differentiated characteristics. Lab Invest 56:211-23 (1987). PubMed PMID: 2433501
Trejdosiewicz LK et al. Phenotypic analysis of cultured melanoma cells. Expression of cytokeratin-type intermediate filaments by the M5 human melanoma cell line. Exp Cell Res 164:388-98 (1986). PubMed PMID: 2423348
Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Format
Purification:
IgG purified
Buffer System:
No Preservative
Purity:
IgG purified
State:
Purified
Specificity
Specificity:
Cytokeratin 7+13+17+18 (LdS 23)
Species:
Human

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