NB120-3117 Cytokeratin antibody

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Mouse anti Human, Monkey, Mouse, Rabbit, Rat Cytokeratin AE1


Product Description for Cytokeratin

Mouse anti Human, Monkey, Mouse, Rabbit, Rat Cytokeratin AE1.
Presentation: Purified
Product is tested for Immunocytochemistry/Immunofluorescence, Western blot / Immunoblot, Paraffin Sections.

Properties for Cytokeratin

Product Category Primary Antibodies
Quantity 0.5 ml
Presentation Purified
Reactivity Hu, Mky, Ms, Rb, Rt
Applications ICC/IF, P, WB
Clonality Monoclonal
Clone AE1
Host Mouse
Isotype IgG1
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Human epidermal keratin.
Isotype control AM03095PU-N, SM10P (for use in human samples), SM20P (for use in rat samples)
Application IHC-P, RT IHC-Frr, IF, WB, ICC
Background Twenty human keratins are resolved with two-dimensional gel electrophoresis into acidic (pI <5.7) and basic (pI >6.0) subfamilies. The acidic keratins have molecular weights of 56.5, 55, 51, 50, 50', 48, 46, 45, and 40kDa. The basic keratins have molecular weights of 65 - 67, 64, 59, 58, 56 and 52kDa. Members of acidic and basic subfamilies are found together in pairs. The composition of keratin pairs varies with cell type, differentiation status and environment. Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis.
General Readings General / background references:Eichner R et al. Classification of epidermal keratins according to their immunoreactivity, isoelectric point, and mode of expression. J Cell Biol 98:1388-96 (1984). PubMed PMID: 6201491
Cooper D et al. The use of aIF, AE1, and AE3 monoclonal antibodies for the identification and classification of mammalian epithelial keratins. Differentiation 28:30-5 (1984). PubMed PMID: 6083891
Woodcock-Mitchell J et al. Immunolocalization of keratin polypeptides in human epidermis using monoclonal antibodies. J Cell Biol 95:580-8 (1982). PubMed PMID: 6183275
Tseng SC et al. Correlation of specific keratins with different types of epithelial differentiation: monoclonal antibody studies. Cell 30:361-72 (1982). PubMed PMID: 6183000
protein G purified
Buffer System:
10mM PBS, pH7.4, 0.2%BSA
protein G purified
Cross-reacts with Human, Rabbit, Rat, Mouse, Cow, Chicken and Monkey. Not yet tested in other species.

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