NBP1-19604 DBC1 antibody

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Rabbit anti Human DBC1


Product Description for DBC1

Rabbit anti Human DBC1.
Presentation: Aff - Purified
Product is tested for Western blot / Immunoblot.

Properties for DBC1

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms anti-KIAA1967 antibody
Presentation Aff - Purified
Reactivity Hu
Applications WB
Clonality Polyclonal
Host Rabbit
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Add. information Research Areas: Cancer
Application Western Blot, This antibody is useful for Western Blot. Western blot analysis of Siah-1/2 (Q210) antibody in extracts from Jurkat cells., Western Blot 1:500-1:1000,
Background DBC-1 (deleted in breast cancer gene 1 protein), also known as p30 DBC protein, is one of the genes located within the region of chromosome 8 (8p21-8p23) that is homozygously deleted in some breast cancers. DBC-1 contains a nuclear localization signal, an N-terminal leucine zipper, an EF hand and a C-terminal coiled-coil region. DBC-1 is closely related to DIS but lacks the SAP domain. During death signaling mediated by TNFalpha, endogenous DBC-1 undergoes caspase-dependent processing to generate DBC-1 p120 and p66, both of which include the C-terminus of the protein. Both DBC-1 p120 and p66 relocate to the cytoplasm. Overexpression of the DBC-1 p120 form results in mitochondrial clustering and matrix condensation and increases the sensitivity of cells to TNFalpha-mediated apoptosis. In addition, DBC-1 directly interacts with unliganded ERalpha, stabilizing its expression and therefore collaborating to suppress apoptosis and promote hormone-independent cell growth.
Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Affinity purified
Buffer System:
No Preservative
Affinity purified
Aff - Purified
DBC-1 (Q455) detects endogenous levels of DBC-1 protein.

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