discontinued

AM00280PU-N Death Domain Receptor 3 / TRAMP antibody

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0.1 mg / €440.00

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Mouse anti Human Death Domain Receptor 3 / TRAMP B65

AM00280PU-N

Product Description for Death Domain Receptor 3 / TRAMP

Mouse anti Human Death Domain Receptor 3 / TRAMP B65.
Presentation: Purified
Product is tested for Immunocytochemistry/Immunofluorescence, Flow Cytometry.

Properties for Death Domain Receptor 3 / TRAMP

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms APO3, Apo-3, Apoptosis-inducing receptor AIR, Apoptosis-mediating receptor DR3, Apoptosis-mediating receptor TRAMP, DDR-3, DDR3, DR-3, DR3, LARD, Lymphocyte-associated receptor of death, TNFRSF12, TNFRSF25, WSL, WSL protein, WSL-1 protein, WSL1
Presentation Purified
Reactivity Hu
Applications F, ICC/IF
Clonality Monoclonal
Clone B65
Host Mouse
Isotype IgG2a
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Immunogen
Immunogen:
Recombinant human DR3 protein.
Remarks:
Mol. Wt. of Antigen: 54 kDa
Isotype control AM03096PU-N
Application Flow Cytometry.
Function Blocking (Not verified)(Order Ab without Azide).
Immunofluorescence.
Background DR3 (also known as Apo3, WSL-1, TRAMP, and LARD) is expressed on lymphocytes. DR3 is one of death domain containing receptors and shows close sequence similarity to TNF receptor I. Upon overexpression, DR3 triggers responses that resemble those of TNFRI, mainly, NF-kB activation and apoptosis. The ligand for DR3 has been identified as Apo3L.
Concentration 0.2 mg/ml
General Readings
  1. Chinnaiyan AM et al. Science 1996, 274(5289):990-2
  2. Kitson J et al. Nature 1996, 384(6607):372-5
  3. Marsters SA et al. Curr Biol 1998, 8(9):525-8
  4. Screaton GR et al. LARD: Proc Natl Acad Sci USA 1997, 94(9):4615-9
  5. Ashkenazi A, and Dixit VM. Science 1998, 281:1305-8
Storage Store the antibody at 2 - 8 °C for one month or in aliquots at -20 °C for longer.
Shelf life: one year from despatch.
Format
Purification:
Protein A chromatography
Buffer System:
10 mM PBS, pH 7.4, with 0.2 % BSA and 0.09 % sodium azide.
State:
Liquid ascites fluid
Purified
Specificity
Specificity:
This antibody detects DR3.
Species:
Human.

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