discontinued

SP6253P Death Domain Receptor 3 / TRAMP antibody

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50 µg / €210.00

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Rabbit anti Human, Mouse, Rat Death Domain Receptor 3 / TRAMP

SP6253P

Product Description for Death Domain Receptor 3 / TRAMP

Rabbit anti Human, Mouse, Rat Death Domain Receptor 3 / TRAMP.
Presentation: Aff - Purified
Product is tested for Western blot / Immunoblot.

Properties for Death Domain Receptor 3 / TRAMP

Product Category Primary Antibodies
Quantity 50 µg
Synonyms APO3, Apo-3, Apoptosis-inducing receptor AIR, Apoptosis-mediating receptor DR3, Apoptosis-mediating receptor TRAMP, DDR-3, DDR3, DR-3, DR3, LARD, Lymphocyte-associated receptor of death, TNFRSF12, TNFRSF25, WSL, WSL protein, WSL-1 protein, WSL1
Presentation Aff - Purified
Reactivity Hu, Ms, Rt
Applications WB
Clonality Polyclonal
Host Rabbit
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer AnaSpec

Datasheet Extract

Immunogen
Immunogen:
Rabbit anti-DR3 (CT) polyclonal antibody was raised against a peptide corresponding to amino acids 398 to 417 of human DR31,2. Peptide available as SP6253CP.
Application Western blot: 1/500 - 1/1000. Jurkat total cell lysate can be used as positive control and a 59 kDa band should be detected. Other applications not tested. Optimal dilutions of this antibody are dependent on conditions and should be determined by the user.
Concentration 0.5 mg/ml
General Readings
  1. Chinnaiyan AM; O'Rourke K; Yu GL; Lyons RH; Garg M; Duan DR; Xing L; Gentz R; Ni J; Dixit VM. Science, 1996;274:990-2.
  2. Kitson J; Raven T; Jiang YP; Goeddel DV; Giles KM; Pun KT; Grinham CJ; Brown R; Farrow SN. Nature, 1996;384:372-5.
  3. Marsters SA; Sheridan JP; Donahue CJ; Pitti RM; Gray CL; Goddard AD; Bauer KD; Ashkenazi A. Curr Biol, 1996;6:1669-76.
  4. Bodmer JL; Burns K; Schneider P; Hofmann K; Steiner V; Thome M; Bornand T; Hahne M; Schroter M; Becker K; et al. Immunity, 1997;6:79-88.
  5. Screaton GR; Xu XN; Olsen AL; Cowper AE; Tan
Storage Store the antibody at 4-8°C for one month or at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Format
State:
Aff - Purified
Specificity
Specificity:
This antibody recognises a 59kD apoptosis related protein designated DR3 (death receptor-3). Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel cell death receptor was recently identified by several groups independently and designated DR3, Wsl-1, Apo-3, TRAMP and LARD1-5. The ligand for this novel cell death receptor has not yet been defined. DR3 is highly expressed in the tissues enriched in lymphocytes including PBL, thymus and spleen. Like TNFR1, DR3 induces apoptosis and NF-?B activation.
The antibody is human, mouse, and rat reactive and has no cross reaction to other death receptors.

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