discontinued

SP6255P Death Domain Receptor 3 / TRAMP antibody

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50 µg / €210.00

Quick Overview

Rabbit anti Human, Mouse Death Domain Receptor 3 / TRAMP

SP6255P

Product Description for Death Domain Receptor 3 / TRAMP

Rabbit anti Human, Mouse Death Domain Receptor 3 / TRAMP.
Presentation: Aff - Purified
Product is tested for Western blot / Immunoblot.

Properties for Death Domain Receptor 3 / TRAMP

Product Category Primary Antibodies
Quantity 50 µg
Synonyms APO3, Apo-3, Apoptosis-inducing receptor AIR, Apoptosis-mediating receptor DR3, Apoptosis-mediating receptor TRAMP, DDR-3, DDR3, DR-3, DR3, LARD, Lymphocyte-associated receptor of death, TNFRSF12, TNFRSF25, WSL, WSL protein, WSL-1 protein, WSL1
Presentation Aff - Purified
Reactivity Hu, Ms
Applications WB
Clonality Polyclonal
Host Rabbit
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer AnaSpec

Datasheet Extract

Immunogen
Immunogen:
Rabbit anti-DR3 (NT) polyclonal antibody was raised against a peptide corresponding to amino acids 25 to 40 of human DR3 precusor1, 2. Peptide available as SP6255CP.
Application Western blot: 1/500 - 1/1000. Jurkat whole cell lysate can be used as positive control and a 59 kDa band can be detected. Other applications not tested. Optimal dilutions of this antibody are dependent on conditions and should be determined by the user.
Concentration 0.5 mg/ml
General Readings
  1. Chinnaiyan AM; O'Rourke K; Yu GL; Lyons RH; Garg M; Duan DR; Xing L; Gentz R; Ni J; Dixit VM. Science, 1996;274:990-2.
  2. Kitson J; Raven T; Jiang YP; Goeddel DV; Giles KM; Pun KT; Grinham CJ; Brown R; Farrow SN. Nature, 1996;384:372-5.
  3. Marsters SA; Sheridan JP; Donahue CJ; Pitti RM; Gray CL; Goddard AD; Bauer KD; Ashkenazi A. Curr Biol, 1996;6:1669-76.
  4. Bodmer JL; Burns K; Schneider P; Hofmann K; Steiner V; Thome M; Bornand T; Hahne M; Schroter M; Becker K; et al. Immunity, 1997;6:79-88.
  5. Screaton GR; Xu XN; Olsen AL; Cowper AE; Tan
Storage Store the antibody at 4-8°C for one month or at -20°C for longer. This product should be stored undiluted. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Format
State:
Aff - Purified
Specificity
Specificity:
This antibody recognises a 59kD apoptosis related protein designated DR3 (death receptor-3). Cross reacts with mouse.
Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel cell death receptor was recently identified by several groups independently and designated DR3, Wsl-1, Apo-3, TRAMP and LARD1-5. The ligand for this novel death receptor has been defined as TWEAK, also termed Apo3L. DR3 is highly expressed in the tissues enriched in lymphocytes including PBL, thymus and spleen. Like TNFR1, DR3 induces apoptosis and NF-?B activation.

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