discontinued

SP7062P Death Domain Receptor 3 / TRAMP antibody

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0.1 mg / €280.00

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Rabbit anti Human Death Domain Receptor 3 / TRAMP

SP7062P

Product Description for Death Domain Receptor 3 / TRAMP

Rabbit anti Human Death Domain Receptor 3 / TRAMP.
Presentation: Purified
Product is tested for Western blot / Immunoblot.

Properties for Death Domain Receptor 3 / TRAMP

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms APO3, Apo-3, Apoptosis-inducing receptor AIR, Apoptosis-mediating receptor DR3, Apoptosis-mediating receptor TRAMP, DDR-3, DDR3, DR-3, DR3, LARD, Lymphocyte-associated receptor of death, TNFRSF12, TNFRSF25, WSL, WSL protein, WSL-1 protein, WSL1
Presentation Purified
Reactivity Hu
Applications WB
Clonality Polyclonal
Host Rabbit
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Immunogen
Immunogen:
Synthetic peptide corresponding to amino acid 59 to 77 in extracellular domain (ED) of human DR3 precusor
Application This polyclonal antibody can be used for detection of DR3 expression by Western blot at 1:500 to 1:1000 dilution. Whole cell lysate from Jurkat cells can be used as positive control and a 59 KDa band should be detected. Since the ligand for DR3 has not been found, this antibody may be useful for receptor engagement to perform function studies of this novel death receptor Optimal dilutions of this antibody are dependent on conditions and should be determined by the user.
Concentration 0.5 mg/ml
General Readings
  1. Chinnaiyan AM; O'Rourke K; Yu GL; Lyons RH; Garg M; Duan DR; Xing L; Gentz R; Ni J; Dixit VM. Science, 1996;274:990-2.
  2. Kitson J; Raven T; Jiang YP; Goeddel DV; Giles KM; Pun KT; Grinham CJ; Brown R; Farrow SN. Nature, 1996;384:372-5.
  3. Marsters SA; Sheridan JP; Donahue CJ; Pitti RM; Gray CL; Goddard AD; Bauer KD; Ashkenazi A. Curr Biol, 1996;6:1669-76.
  4. Bodmer JL; Burns K; Schneider P; Hofmann K; Steiner V; Thome M; Bornand T; Hahne M; Schroter M; Becker K; et al. Immunity, 1997;6:79-88.
  5. Screaton GR; Xu XN; Olsen AL; Cowper AE; Tan
Storage Store the antibody at 4-8°C for one month or at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Format
State:
Purified
Specificity
Specificity:
Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel cell death receptor was recently identified by several groups independently and designated DR3, Wsl-1, Apo-3, TRAMP and LARD1-5. The ligand for this novel cell death receptor has not yet been defined. DR3 is highly expressed in the tissues enriched in lymphocytes including PBL, thymus and spleen. Like TNFR1, DR3 induces apoptosis and NF-kB activation This antibody is specific for human DR2/TRAMP/Wsl-1.

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