discontinued

NB100-55821 Decoy receptor 1 antibody

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0.1 mg / €400.00

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Rabbit anti Human, Mouse, Rat Decoy receptor 1

NB100-55821

Product Description for Decoy receptor 1

Rabbit anti Human, Mouse, Rat Decoy receptor 1.
Presentation: Aff - Purified
Product is tested for Western blot / Immunoblot.

Properties for Decoy receptor 1

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms Decoy TRAIL receptor without death domain, TNF-related apoptosis-inducing ligand receptor 3, Tumor necrosis factor receptor superfamily member 10C
Presentation Aff - Purified
Reactivity Hu, Ms, Rt
Applications WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Immunogen
Immunogen:
Human DcR1 (ED2) peptide.
Background Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family and induces apoptosis of a variety of tumor cell lines. DR4 and DR5 are the recently identified functional receptors for TRAIL. Two decoy receptors for TRAIL have been identified and designated DcR1/TRID/TRAIL-R3/LIT and DcR2/TRAIL-R4/TRUNDD. DcR1 has extracellular TRAIL-binding domain but lacks intracellular signaling domain. It is a glycophospholipid-anchored cell surface protein. DcR1 transcripts are expressed in many normal human tissues but not in most cancer cell lines. Overexpression of DcR1 did not induce apoptosis, but attenuated TRAIL-induced apoptosis.
Storage Store at 4C. Do not freeze.
Format
Purification:
Peptide Affinity Purified
Buffer System:
PBS containing 0.02% sodium azide.
Purity:
Peptide Affinity Purified
State:
Aff - Purified
Specificity
Species:
Human, Mouse, Rat Not yet tested in other species.

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