AP54886SU-N Delta-2 Tubulin (Detyrosinated & Decarboxylated alpha-Tubulin) antibody

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0.2 ml / €400.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

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Rabbit anti Human Delta-2 Tubulin


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  • AP54886SU-N

Product Description for Delta-2 Tubulin

Rabbit anti Human Delta-2 Tubulin.
Properties: (Detyrosinated & Decarboxylated alpha-Tubulin)
Presentation: Serum
Product is tested for Frozen Sections, Enzyme Immunoassay, Western blot / Immunoblot.

Properties for Delta-2 Tubulin

Product Category Primary Antibodies
Quantity 0.2 ml
Presentation Serum
Reactivity Hu
Applications C, E, WB
Clonality Polyclonal
Host Rabbit
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Synthetic peptides derived from C-terminal domain of Human Tubulin
Property Detyrosinated & Decarboxylated alpha-Tubulin

Western Blot: 1/500-1/2000.
Immunohistochemistry: 1/50-1/200.

Background Microtubules are involved in a wide variety of cellular activities ranging from mitosis and transport events to cell movement and the maintenance of cell shape. Tubulin itself is a globular protein which consists of two polypeptides (alpha and beta tubulin). Alpha and beta tubulin dimers are assembled to 13 protofilaments that form a microtubule of 22 nm diameter. Tyrosine ligase adds a C-terminal tyrosin to monomeric alpha tubulin. Assembled microtubules can again be detyrosinated by a cytoskeleton associated carboxypeptidase. Detyrosinated alpha tubulin is referred to as Glu-tubulin. Another post-translational modification of detyrosinated alpha tubulin is C-terminal polyglutamylation which is characteristic for microtubules in neuronal cells and the mitotic spindle. Alpha tubulin is not suitable as a loading control in adipose tissue as expression of tubulin in adipose tissue is very low ( Spiegelman and Farmer, Cell, 1982, 29(1): 53-60, "in cells undergoing adipose differentiation actin synthesis decreases by 90%").
General Readings
  1. Walter WJ, Beránek V, Fischermeier E, Diez S. Tubulin acetylation alone does not affect kinesin-1 velocity and run length in vitro. PLoS One. 2012;7(8):e42218. doi: 10.1371/journal.pone.0042218. Epub 2012 Aug 1. PubMed PMID: 22870307. (Free PMC Article available, 3 images available)
  2. Peris L, Thery M, Fauré J, Saoudi Y, Lafanechère L, Chilton JK, et al. Tubulin tyrosination is a major factor affecting the recruitment of CAP-Gly proteins at microtubule plus ends. J Cell Biol. 2006 Sep 11;174(6):839-49. Epub 2006 Sep 5. PubMed PMID: 16954346. (Free PMC Article available, 8 images available)
  3. Mialhe A, Lafanechère L, Treilleux I, Peloux N, Dumontet C, Brémond A, et al. Tubulin detyrosination is a frequent occurrence in breast cancers of poor prognosis. Cancer Res. 2001 Jul 1;61(13):5024-7. PubMed PMID: 11431336.
Storage Store lyophilized at 2-8°C for 6 months or at -20°C long term.
After reconstitution store the antibody undiluted at 2-8°C for one month 
or (in aliquots) at -20°C long term.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Lyophilized powder
Restore in distilled water.
Species Reactivity
Species reactivity (tested):
Reacts with Delta-2 Tubulin (Detyrosinated and Decarboxylated alpha-Tubulin).

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