AP13670PU-N Deoxyguanosine kinase (C-term) antibody

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0.4 ml / €370.00
Please visit the country specific website of OriGene Technologies or contact your local Distributor to buy this product.

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Rabbit anti Human, Mouse Deoxyguanosine kinase

Product Description for Deoxyguanosine kinase

Rabbit anti Human, Mouse Deoxyguanosine kinase.
Properties: (C-term)
Presentation: Purified
Product is tested for Western blot / Immunoblot.

Properties for Deoxyguanosine kinase

Product Category Primary Antibodies
Target Category
Quantity 0.4 ml
Synonyms DGK, DGUOK
Presentation Purified
Reactivity Hu, Ms
Applications WB
Clonality Polyclonal
Host Rabbit
Isotype Ig
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer OriGene Technologies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
Q16854
Immunogen:
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human DGUOK.
GeneID:
1716
Property C-term
Application ELISA: 1/1,000.
Western blotting: 1/100 - 1/500.
Background Mitochondrial deoxyguanosine kinase (DGUOK) is required for the phosphorylation of several deoxyribonucleosides and certain purine deoxykribonucleoside analogs widely employed as antiviral and chemotherapeutic agents. Purine deoxyribonucleoside analogs are extensively used in treatment of lymphoproliferative disorders. These compounds are administered as pro-drugs, and their efficiency is dependent on intracellular phosphorylation to the corresponding triphosphates. In mammalian cells, the phosphorylation of purine deoxyribonucleosides is mediated predominantly by 2 deoxyribonucleoside kinases: cytosolic deoxycytidine kinase (DCK) and mitochondrial deoxyguanosine kinase (DGUOK also known as DGK). DGUOK expression is ubiquitous, with highest levels in muscle, brain, liver and lymphoid tissues. Defects in DGUOK are a cause of mitochondrial DNA depletion syndrome (MDS). MDS is a clinically heterogeneous group of disorders characterized by a reduction in mitochondrial DNA (mtDNA) copy number. Primary mtDNA depletion is inherited as an autosomal recessive trait and may affect single organs, typically muscle or liver, or multiple tissues. Mitochondrial DNA depletion syndromes are phenotypically heterogeneous, autosomal recessive disorders characterized by tissue-specific reduction in mtDNA copy number. Affected individuals with the hepatocerebral form of mtDNA depletion syndrome have early progressive liver failure and neurologic abnormalities, hypoglycemia, and increased lactate in body fluids.
Caution This product is for research use only. Not for use in diagnostic or therapeutic procedures.
Concentration lot specific
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
Purification:
Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
Buffer System:
PBS with 0.09% (W/V) sodium azide
State:
Liquid purified Ig
Purified
Specificity
Specificity:
This antibody reacts to Deoxyguanosine Kinase (DGUOK).
Species:
Human, Mouse.
Gene ID 1716

Accessory Products

Proteins and/or Positive Controls

Proteins for Deoxyguanosine kinase (6 products)

Catalog No. Species Pres. Purity   Source  

Deoxyguanosine kinase (transcript variant 1)

Deoxyguanosine kinase Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Deoxyguanosine kinase

Deoxyguanosine kinase Human in vitro transl.
  Abnova Taiwan Corp.

Deoxyguanosine kinase

Deoxyguanosine kinase Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

Deoxyguanosine kinase

Deoxyguanosine kinase Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

Deoxyguanosine kinase

Deoxyguanosine kinase Human
  Abnova Taiwan Corp.

Deoxyguanosine kinase

Deoxyguanosine kinase Human
  Abnova Taiwan Corp.

Positive controls for Deoxyguanosine kinase (1 products)

Catalog No. Species Pres. Purity   Source  

Deoxyguanosine kinase Lysate

Western Blot: Deoxyguanosine kinase Lysate [NBL1-09856] - Western Blot experiments. 
Left-Control; Right -Over-expression Lysate for DGUOK
  Novus Biologicals Inc.
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