NBP1-22542 Desmin (D33) antibody

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Mouse anti Chicken, Human, Rat Desmin (D33) D33

Product Description for Desmin (D33)

Mouse anti Chicken, Human, Rat Desmin (D33) D33.
Presentation: Supernatant
Product is tested for Paraffin Sections.

Properties for Desmin (D33)

Product Category Primary Antibodies
Quantity 0.5 ml
Synonyms anti-CMD1I antibody, anti-CSM1 antibody, anti-CSM2 antibody, anti-DES antibody, anti-FLJ12025 antibody, anti-FLJ39719 antibody, anti-FLJ41013 antibody, anti-FLJ41793 antibody, anti-Intermediate filament protein antibody, anti-OTTHUMP00000064865 antibody
Presentation Supernatant
Reactivity Chk, Hu, Rt
Applications P
Clonality Monoclonal
Clone D33
Host Mouse
Isotype IgG1
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

BALB/C mice were immunized with purified desmin from human muscle.
Application immunohistochemistry, ABC, immunohistochemistry 1:25-1:50
Background Desmins belongs to the intermediate filament family, and are class III intermediate filaments found in muscle cells. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z line structures. Defects in Desmin are the cause of desmin related cardio skeletal myopathy (CSM) also known as desmin related myopathy (DRM). CSM is characterized by skeletal muscle weakness associated with cardiac conduction blocks, arrhythmias, restrictive heart failure, and by intracytoplasmic accumulation of desmin reactive deposits in cardiac and skeletal muscle cells. A desmin related myopathy can have a distal onset, it is then known as hereditary distal myopathy (HDM). Defects in Desmin are also the cause of dilated cardiomyopathy type 1I (CMD1I). CMD1I is an autosomal form of dilated cardiomyopathy characterized by ventricular dilatation and impaired systolic function. Antidesmin antibodies are useful in identification of tumours of myogenic origin. This antibody stains muscle cells in human tissues
Storage Store at 4C. Do not freeze.
Tissue culture supernatant
Buffer System:
Sodium Azide
Tissue culture supernatant
This reacts with desmin protein of 53 kD. Both striated as well as smooth muscle cells stain well with this. The antibody shows a broad interspecific cross-reactivity i.e. reacts with human, rat, chicken and hamster.
Chicken, Hamster, Human, Rat

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