GTX22862 Dihydropyridine Receptor Alpha 1 antibody

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0.2 ml / €380.00

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Mouse anti Guinea Pig, Human, Mouse, Rabbit, Rat Dihydropyridine Receptor Alpha 1 1A

Product Description for Dihydropyridine Receptor Alpha 1

Mouse anti Guinea Pig, Human, Mouse, Rabbit, Rat Dihydropyridine Receptor Alpha 1 1A.
Presentation: Ascites
Product is tested for Immunoprecipitation, Western blot / Immunoblot.

Properties for Dihydropyridine Receptor Alpha 1

Product Category Primary Antibodies
Quantity 0.2 ml
Synonyms DHPR alpha 1
Presentation Ascites
Reactivity GP, Hu, Ms, Rb, Rt
Applications IP, WB
Clonality Monoclonal
Clone 1A
Host Mouse
Isotype IgG1
Shipping to Europe only
PDF datasheet View Datasheet
Manufacturer GeneTex Inc.

Datasheet Extract

Purified rabbit muscle T-tubule dihydropyridine receptor.
Application IHC-Fr, IP, WB
Background Voltage-sensitive calcium channels mediate the entry of calcium into many types of excitable cells and thus play a key role in neurotransmitter release and excitation-contraction (E-C) coupling. The 1,4-dihydropyridines (DHPs) are synthetic organic compounds which can be used to identify the L-type calcium channels that are found in all types of vertebrate muscle, neuronal and neuroendocrine cells. The DHP receptor is part of the L-type calcium channel complex and is thought to be the voltage sensor in E-C coupling. The purified DHP receptor isolated from triads is composed of at least four subunits. The alpha-1 subunit contains the binding site for the DHPs and shows high sequence homology to the voltage gated sodium channel. The alpha-2 subunit is a large glycoprotein associated with the DHP receptor which was first described in skeletal muscle and is also found in high concentrations in other excitable tissues such as cardiac muscle and brain and in low concentrations in most other tissues studied. The other two subunits that co-purify with the DHP receptor are termed beta and gamma.
Storage Upon receipt - Keep as concentrated solution. Aliquot and store at -20
Buffer System:
Ascites with 0.05% sodium azide
Cross-reacts with Human, Rabbit, Rat, Mouse and Guinea pig. Not yet tested in other species.

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